Cell Biology Antibodies 8

Anti-CLDN7 Antibody (CAB2035)

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SKU:
CAB2035
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLDN7 Antibody
Antibody SKU:CAB2035
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, HT-29, A-549, HO-8910PM, Mouse lung, Mouse kidney, Mouse liver, rat kidney, rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QWQM SSYA GDNI ITAQ AMYK GLWM DCVT QSTG MMSC KMYD SVLA LSAA LQAT RALM VVSL VLGF LAMF VATM GMKC TRCG GDDK VKKA RIAM GGGI IFIV AGLA ALVA CSWY GHQI VTDF YNPL IPTN IKYE FGPA IFIG WAGS ALVI LGGA LLSC SCPG NESK AGYR VPRS YPKS NSSK EYV
Gene ID:1366
Uniprot:O95471
Cellular Location:Cell junction, Cell membrane, Lateral cell membrane, Multi-pass membrane protein, tight junction
Calculated MW:16kDa/22kDa
Observed MW:29kDa
Synonyms:CLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin-7
Background:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
UniProt Protein Function:Claudin-7: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: apicolateral plasma membrane; basolateral plasma membrane; integral to membrane; lateral plasma membrane; tight junction

Molecular Function:cell adhesion molecule binding; identical protein binding; protein binding; structural molecule activity

Biological Process: calcium-independent cell-cell adhesion; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of protein homooligomerization; positive regulation of cell proliferation; positive regulation of defense response to virus by host

NCBI Summary:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
UniProt Code:O95471
NCBI GenInfo Identifier:311033475
NCBI Gene ID:1366
NCBI Accession:O95471.4
UniProt Secondary Accession:O95471,Q6IPN3, Q7Z4Y7, Q9BVN0, B2R9X7, D3DTP0,
UniProt Related Accession:O95471
Molecular Weight:16,837 Da
NCBI Full Name:Claudin-7
NCBI Synonym Full Names:claudin 7
NCBI Official Symbol:CLDN7  
NCBI Official Synonym Symbols:CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1  
NCBI Protein Information:claudin-7
UniProt Protein Name:Claudin-7
Protein Family:Claudin
UniProt Gene Name:CLDN7  
UniProt Entry Name:CLD7_HUMAN
Anti-CLDN7 Antibody (CAB2035)Western blot analysis of extracts of various cell lines, using CLDN7 antibody (CAB2035) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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