Anti-CLDN6 Antibody (CAB20465)
- SKU:
- CAB20465
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Product Name: | CLDN6 Rabbit pAb |
| Product Code: | CAB20465 |
| Size: | 50uL, 100uL |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CLDN6. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | OVCAR3, Rat brain |
| Immunogen: | Recombinant protein of human CLDN6. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9074 |
| Uniprot: | P56747 |
| Calculated MW: | 23kDa |
| Observed MW: | 23KDa |
| UniProt Protein Function: | Claudin-6: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: tight junction Molecular Function:identical protein binding Biological Process: calcium-independent cell-cell adhesion |
| NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010] |
| UniProt Code: | P56747 |
| NCBI GenInfo Identifier: | 90183180 |
| NCBI Gene ID: | 9074 |
| NCBI Accession: | P56747.2 |
| UniProt Secondary Accession: | P56747,B3KQP9, D3DUA5, |
| UniProt Related Accession: | P56747 |
| Molecular Weight: | 23,292 Da |
| NCBI Full Name: | Claudin-6 |
| NCBI Synonym Full Names: | claudin 6 |
| NCBI Official Symbol: | CLDN6 |
| NCBI Protein Information: | claudin-6 |
| UniProt Protein Name: | Claudin-6 |
| UniProt Synonym Protein Names: | Skullin |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN6 |
| UniProt Entry Name: | CLD6_HUMAN |
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