Name: Anti-CLDN19 Antibody (CAB2874)
Brand: Signal Transduction Antibodies 2
SKU: CAB2874
Availability: OutOfStock

Antibody Name:	Anti-CLDN19 Antibody
Antibody SKU:	CAB2874
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN19 (NP_001116867.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	293T, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN19 (NP_001116867.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GIIA STAL PQWK QSSY AGDA IITA VGLY EGLW MSCA SQST GQVQ CKLY DSLL ALDG HIQS A
Gene ID:	149461
Uniprot:	Q8N6F1
Cellular Location:	Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
Calculated MW:	22kDa/23kDa
Observed MW:	23kDa

Synonyms:

CLDN19, HOMG5

Background:

The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

UniProt Protein Function:	Claudin-19: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN19 are the cause of hypomagnesemia renal with ocular involvement (HOMG5). HOMG5 is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The renal phenotype is virtually undistinguishable from that of patients with HOMG3 with proven CLDN16 mutations. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: apical junction complex; tight junction; basolateral plasma membrane; cytoplasm; integral to membrane; nucleus Molecular Function:identical protein binding; structural molecule activity Biological Process: apical junction assembly; visual perception; response to stimulus; action potential propagation; calcium-independent cell-cell adhesion Disease: Hypomagnesemia 5, Renal, With Ocular Involvement
NCBI Summary:	The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
UniProt Code:	Q8N6F1
NCBI GenInfo Identifier:	47606757
NCBI Gene ID:	149461
NCBI Accession:	Q8N6F1.2
UniProt Secondary Accession:	Q8N6F1,Q5QT57, Q8N8X0, B7Z5I2, F5H5P9,
UniProt Related Accession:	Q8N6F1
Molecular Weight:	224
NCBI Full Name:	Claudin-19
NCBI Synonym Full Names:	claudin 19
NCBI Official Symbol:	CLDN19
NCBI Official Synonym Symbols:	HOMG5
NCBI Protein Information:	claudin-19
UniProt Protein Name:	Claudin-19
Protein Family:	Claudin
UniProt Gene Name:	CLDN19
UniProt Entry Name:	CLD19_HUMAN

Western blot analysis of extracts of various cell lines, using CLDN19 Antibody (CAB2874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s.

Antibodies

CLDN19 Antibody (PACO00606)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)