Signal Transduction Antibodies 2

Anti-CLDN17 Antibody (CAB15151)

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SKU:
CAB15151
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CLDN17 Antibody
Antibody SKU:CAB15151
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_036263.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Rat kidney
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_036263.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CGMK QVQC TGSN ERAK AYLL GTSG VLFI LTGI FVLI PVSW TANI IIRD FYNP AIHI GQKR ELGA ALFL GWAS AAVL FIGG GLLC GFCC CNRK KQGY RYPV PGYR VPHT DKRR NTTM LSKT STSY V
Gene ID:26285
Uniprot:P56750
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
Calculated MW:24kDa
Observed MW:29kDa
Synonyms:CLDN17
Background:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11.
UniProt Protein Function:Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.
NCBI Summary:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]
UniProt Code:P56750
NCBI GenInfo Identifier:6912316
NCBI Gene ID:26285
NCBI Accession:NP_036263.1
UniProt Secondary Accession:P56750,Q3MJB5, Q6UY37,
UniProt Related Accession:P56750
Molecular Weight:25 kDa
NCBI Full Name:claudin-17
NCBI Synonym Full Names:claudin 17
NCBI Official Symbol:CLDN17  
NCBI Protein Information:claudin-17
UniProt Protein Name:Claudin-17
Protein Family:Claudin
UniProt Gene Name:CLDN17  
Anti-CLDN17 Antibody (CAB15151)Western blot analysis of extracts of various cell lines, using CLDN17 antibody (CAB15151) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-CLDN17 Antibody (CAB15151)Immunohistochemistry of paraffin-embedded mouse kidney using CLDN17 antibody (CAB15151) at dilution of 1:100 (40x lens).
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