Signal Transduction Antibodies 1
Anti-CLDN12 Antibody (CAB10709)
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- SKU:
- CAB10709
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CLDN12 Antibody |
| Antibody SKU: | CAB10709 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN12 (NP_001172001.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN12 (NP_001172001.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGCR DVHA ATVL SFLC GIAS VAGL FAGT LLPN WRKL RLIT FNRN EKNL TVYT GLWV KCAR YDGS SDCL MYDT TWYS SVDQ LDLR VLQF ALPL SMLI AMGA |
| Gene ID: | 9069 |
| Uniprot: | P56749 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| Calculated MW: | 27kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | CLDN12 |
| Background: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. |
| UniProt Protein Function: | Claudin-12: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q21.13 Cellular Component: plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011] |
| UniProt Code: | P56749 |
| NCBI GenInfo Identifier: | 6685308 |
| NCBI Gene ID: | 9069 |
| NCBI Accession: | P56749.1 |
| UniProt Secondary Accession: | P56749,Q7LDZ0, D6W5Q4, |
| UniProt Related Accession: | P56749 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Claudin-12 |
| NCBI Synonym Full Names: | claudin 12 |
| NCBI Official Symbol: | CLDN12 |
| NCBI Protein Information: | claudin-12 |
| UniProt Protein Name: | Claudin-12 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN12 |
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