Signal Transduction Antibodies 1

Anti-CLDN12 Antibody (CAB10709)

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SKU:
CAB10709
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CLDN12 Antibody
Antibody SKU:CAB10709
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN12 (NP_001172001.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN12 (NP_001172001.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGCR DVHA ATVL SFLC GIAS VAGL FAGT LLPN WRKL RLIT FNRN EKNL TVYT GLWV KCAR YDGS SDCL MYDT TWYS SVDQ LDLR VLQF ALPL SMLI AMGA
Gene ID:9069
Uniprot:P56749
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
Calculated MW:27kDa
Observed MW:Refer to Figures
Synonyms:CLDN12
Background:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.
UniProt Protein Function:Claudin-12: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q21.13

Cellular Component: plasma membrane; tight junction

Molecular Function:identical protein binding; protein binding

Biological Process: calcium-independent cell-cell adhesion

NCBI Summary:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]
UniProt Code:P56749
NCBI GenInfo Identifier:6685308
NCBI Gene ID:9069
NCBI Accession:P56749.1
UniProt Secondary Accession:P56749,Q7LDZ0, D6W5Q4,
UniProt Related Accession:P56749
Molecular Weight:27kDa
NCBI Full Name:Claudin-12
NCBI Synonym Full Names:claudin 12
NCBI Official Symbol:CLDN12  
NCBI Protein Information:claudin-12
UniProt Protein Name:Claudin-12
Protein Family:Claudin
UniProt Gene Name:CLDN12  
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