Cell Biology Antibodies 13

Anti-CLCN6 Antibody (CAB17458)

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SKU:
CAB17458
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLCN6 Antibody
Antibody SKU:CAB17458
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CLCN6 (NP_001277.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:100
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CLCN6 (NP_001277.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGC RGSL CCCC RWCC CCGE RETR TPEE LTIL GETQ EEED EILP RKDY ESLD YDRC INDP YLEV LETM DNKK GRRY EAVK
Gene ID:1185
Uniprot:P51797
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Anti-CLCN6 Antibody (CAB17458)Immunohistochemistry - CLCN6 Polyclonal Antibody (CAB17458)
Synonyms:CLC-6, CLCN6
Background:This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
UniProt Protein Function:Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
UniProt Protein Details:

Subcellular location: Endosome membrane; Multi-pass membrane protein. Note: Detected in detergent-resistant lipid rafts. Ref.11

Tissue specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. Ref.1 Ref.2 Ref.10

Post-translational modification: N-glycosylated on several asparagine residues. Ref.11

Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters

By similarity.

Sequence similarities: Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. [View classification]Contains 2 CBS domains.

NCBI Summary:This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
UniProt Code:P51797
NCBI GenInfo Identifier:4502873
NCBI Gene ID:1185
NCBI Accession:NP_001277
UniProt Related Accession:P51797
Molecular Weight:93kDa
NCBI Full Name:chloride transport protein 6 isoform 1
NCBI Synonym Full Names:chloride voltage-gated channel 6
NCBI Official Symbol:CLCN6  
NCBI Official Synonym Symbols:CLC-6  
NCBI Protein Information:chloride transport protein 6
UniProt Protein Name:Chloride transport protein 6
UniProt Synonym Protein Names:Chloride channel protein 6
Protein Family:Chloride transport protein
UniProt Gene Name:CLCN6  
UniProt Entry Name:CLCN6_HUMAN
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