Signal Transduction Antibodies 2

Anti-CLCN3 Antibody (CAB17452)

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SKU:
CAB17452
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CLCN3 Antibody
Antibody SKU:CAB17452
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CLCN3.
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide of human CLCN3.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1182
Uniprot:P51790
Cellular Location:Cytoplasmic vesicle, Early endosome membrane, Golgi apparatus membrane, Late endosome membrane, Membrane, Multi-pass membrane protein, Multi-pass membrane protein, secretory vesicle membrane
Calculated MW:88kDa/90kDa/96kDa
Observed MW:Refer to figures
Synonyms:CLCN3, CLC3, ClC-3
Background:This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Summary:This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Code:P51790
NCBI GenInfo Identifier:226693513
NCBI Gene ID:1182
NCBI Accession:P51790.2
UniProt Related Accession:P51790
Molecular Weight:88kDa; 90kDa; 96kDa
NCBI Full Name:H(+)/Cl(-) exchange transporter 3
NCBI Synonym Full Names:chloride voltage-gated channel 3
NCBI Official Symbol:CLCN3  
NCBI Official Synonym Symbols:CLC3; ClC-3  
NCBI Protein Information:H(+)/Cl(-) exchange transporter 3
UniProt Protein Name:H(+)/Cl(-) exchange transporter 3
UniProt Synonym Protein Names:Chloride channel protein 3; ClC-3; Chloride transporter ClC-3
Protein Family:H(+)/Cl(-) exchange transporter
UniProt Gene Name:CLCN3  
UniProt Entry Name:CLCN3_HUMAN
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