Cell Biology Antibodies 14

Anti-CLCA2 Antibody (CAB17056)

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SKU:
CAB17056
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLCA2 Antibody
Antibody SKU:CAB17056
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-160 of human CLCA2 (NP_006527.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-160 of human CLCA2 (NP_006527.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GVQL QDNG YNGL LIAI NPQV PENQ NLIS NIKE MITE ASFY LFNA TKRR VFFR NIKI LIPA TWKA NNNS KIKQ ESYE KANV IVTD WYGA HGDD PYTL QYRG CGKE GKYI HFTP NFLL NDNL TAGY GSRG R
Gene ID:9635
Uniprot:Q9UQC9
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:CLCA2, CACC, CACC3, CLCRG2, CaCC-3
Background:This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines.
UniProt Protein Function:CLCA5: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family.
UniProt Protein Details:

Protein type:Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; basal plasma membrane; cell junction

Molecular Function:chloride channel activity; metallopeptidase activity; metal ion binding; ligand-gated ion channel activity

Biological Process: transport; proteolysis; cell adhesion; transmembrane transport

NCBI Summary:The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UQC9
NCBI GenInfo Identifier:5729769
NCBI Gene ID:9635
NCBI Accession:NP_006527.1
UniProt Secondary Accession:Q9UQC9,Q9Y6N2, A8K2T3,
UniProt Related Accession:Q9UQC9
Molecular Weight:103,941 Da
NCBI Full Name:calcium-activated chloride channel regulator 2
NCBI Synonym Full Names:chloride channel accessory 2
NCBI Official Symbol:CLCA2  
NCBI Official Synonym Symbols:CACC; CACC3; CLCRG2; CaCC-3  
NCBI Protein Information:calcium-activated chloride channel regulator 2
UniProt Protein Name:Calcium-activated chloride channel regulator 2
UniProt Synonym Protein Names:Calcium-activated chloride channel family member 2; hCLCA2
Protein Family:Calcium-activated chloride channel regulator
UniProt Gene Name:CLCA2  
UniProt Entry Name:CLCA2_HUMAN
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