Antibody Name:	CLDN8 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8174
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse lung, Mouse kidney, Mouse pancreas, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QWRV SAFI ENNI VVFE NFWE GLWM NCVR QANI RMQC KIYD SLLA LSPD LQAA R
Gene ID:	9073
Uniprot:	P56748
Cellular Location:	Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
Calculated MW:	24kDa
Observed MW:	28kDa

Synonyms:

CLDN8, HEL-S-79, claudin-8

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.

UniProt Protein Function:	Claudin-8: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: endoplasmic reticulum; plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion
NCBI Summary:	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
UniProt Code:	P56748
NCBI GenInfo Identifier:	6685307
NCBI Gene ID:	9073
NCBI Accession:	P56748.1
UniProt Secondary Accession:	P56748,Q53EX7, D3DSE3,
UniProt Related Accession:	P56748
Molecular Weight:	24,845 Da
NCBI Full Name:	Claudin-8
NCBI Synonym Full Names:	claudin 8
NCBI Official Symbol:	CLDN8
NCBI Official Synonym Symbols:	HEL-S-79
NCBI Protein Information:	claudin-8
UniProt Protein Name:	Claudin-8
Protein Family:	Claudin
UniProt Gene Name:	CLDN8
UniProt Entry Name:	CLD8_HUMAN