Signal Transduction Antibodies 3
Anti-Claudin-10 Antibody (CAB9853)
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- SKU:
- CAB9853
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Claudin-10 Antibody |
| Antibody SKU: | CAB9853 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN10 (NP_008915.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN10 (NP_008915.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAST ASEI IAFM VSIS GWVL VSST LPTD YWKV STID GTVI TTAT YWAN LWKA CVTD STGV SNCK DFPS MLAL DGYI QACR GLMI AAVS LGFF GSIF ALFG |
| Gene ID: | 9071 |
| Uniprot: | P78369 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| Calculated MW: | 22kDa/24kDa |
| Observed MW: | 26kDa |
| Synonyms: | CLDN10, CPETRL3, OSP-L |
| Background: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined. |
| UniProt Protein Function: | Claudin-10: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 13q32.1 Cellular Component: tight junction Molecular Function:identical protein binding Biological Process: calcium-independent cell-cell adhesion; cell adhesion |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010] |
| UniProt Code: | P78369 |
| NCBI GenInfo Identifier: | 6685311 |
| NCBI Gene ID: | 9071 |
| NCBI Accession: | P78369.2 |
| UniProt Secondary Accession: | P78369,Q6IBF9, Q96N78, |
| UniProt Related Accession: | P78369 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Claudin-10 |
| NCBI Synonym Full Names: | claudin 10 |
| NCBI Official Symbol: | CLDN10 |
| NCBI Official Synonym Symbols: | OSP-L; CPETRL3 |
| NCBI Protein Information: | claudin-10 |
| UniProt Protein Name: | Claudin-10 |
| UniProt Synonym Protein Names: | OSP-like protein |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN10 |
 | Western blot analysis of extracts of rat lung, using CLDN10 antibody (CAB9853) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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