Cell Cycle Antibodies 1

Anti-CLASP2 Antibody (CAB4528)

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SKU:
CAB4528
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CLASP2

Description

Product Name:CLASP2 Rabbit pAb
Product Code:CAB4528
Size:20uL, 50uL, 100uL
Synonyms:CLASP2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse eye, Mouse brain, Mouse lung, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NCTS KSVP VRRR SFEF LDLL LQEW QTHS LERH AAVL VETI KKGI HDAD AEAR VEAR KTYM GLRN HFPG EAET LYNS LEPS YQKS LQTY LKSS GSVA SLPQ SDRS SSSS QESL NRPF SSKW STAN PSTV AGRV SAGS SKAS SLPG SLQR SRSD IDVN AAAG AKAH HAAG QSVR SGRL GAGA L
Gene ID:23122
Uniprot:O75122
Cellular Location:Cell membrane, Cell projection, Chromosome, Cytoplasm, Golgi apparatus, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, ruffle membrane, spindle, trans-Golgi network
Calculated MW:46kDa/141kDa/165kDa
Observed MW:141kDa
UniProt Protein Function:CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: kinetochore microtubule; Golgi apparatus; microtubule; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; microtubule organizing center; cell cortex; trans-Golgi network; cytosol

Molecular Function:microtubule plus-end binding; protein binding; galactoside 2-alpha-L-fucosyltransferase activity

Biological Process: mitosis; microtubule organizing center organization and biogenesis; axon guidance; regulation of microtubule-based process; cell division; negative regulation of microtubule depolymerization; establishment and/or maintenance of cell polarity; mitotic cell cycle; microtubule nucleation; regulation of microtubule polymerization or depolymerization

UniProt Code:O75122
NCBI GenInfo Identifier:77416392
NCBI Gene ID:
NCBI Accession:O75122.2
Molecular Weight:
NCBI Full Name:CLIP-associating protein 2
UniProt Protein Name:CLIP-associating protein 2
UniProt Synonym Protein Names:Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
UniProt Gene Name:CLASP2  
UniProt Entry Name:CLAP2_HUMAN
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