Description
| Product Name: | CLASP2 Rabbit pAb |
| Product Code: | CAB4528 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CLASP2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye, Mouse brain, Mouse lung, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NCTS KSVP VRRR SFEF LDLL LQEW QTHS LERH AAVL VETI KKGI HDAD AEAR VEAR KTYM GLRN HFPG EAET LYNS LEPS YQKS LQTY LKSS GSVA SLPQ SDRS SSSS QESL NRPF SSKW STAN PSTV AGRV SAGS SKAS SLPG SLQR SRSD IDVN AAAG AKAH HAAG QSVR SGRL GAGA L |
| Gene ID: | 23122 |
| Uniprot: | O75122 |
| Cellular Location: | Cell membrane, Cell projection, Chromosome, Cytoplasm, Golgi apparatus, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, ruffle membrane, spindle, trans-Golgi network |
| Calculated MW: | 46kDa/141kDa/165kDa |
| Observed MW: | 141kDa |
| UniProt Protein Function: | CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: kinetochore microtubule; Golgi apparatus; microtubule; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; microtubule organizing center; cell cortex; trans-Golgi network; cytosol Molecular Function:microtubule plus-end binding; protein binding; galactoside 2-alpha-L-fucosyltransferase activity Biological Process: mitosis; microtubule organizing center organization and biogenesis; axon guidance; regulation of microtubule-based process; cell division; negative regulation of microtubule depolymerization; establishment and/or maintenance of cell polarity; mitotic cell cycle; microtubule nucleation; regulation of microtubule polymerization or depolymerization |
| UniProt Code: | O75122 |
| NCBI GenInfo Identifier: | 77416392 |
| NCBI Gene ID: | |
| NCBI Accession: | O75122.2 |
| Molecular Weight: | |
| NCBI Full Name: | CLIP-associating protein 2 |
| UniProt Protein Name: | CLIP-associating protein 2 |
| UniProt Synonym Protein Names: | Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2 |
| UniProt Gene Name: | CLASP2 |
| UniProt Entry Name: | CLAP2_HUMAN |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Polyclonal Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Synonyms: |
CLASP2 |
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