Cell Biology Antibodies 8
Anti-CKM Antibody (CAB2024)
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- SKU:
- CAB2024
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CKM Antibody |
| Antibody SKU: | CAB2024 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-381 of human CKM (NP_001815.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-381 of human CKM (NP_001815.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPFG NTHN KFKL NYKP EEEY PDLS KHNN HMAK VLTL ELYK KLRD KETP SGFT VDDV IQTG VDNP GHPF IMTV GCVA GDEE SYEV FKEL FDPI ISDR HGGY KPTD KHKT DLNH ENLK GGDD LDPN YVLS SRVR TGRS IKGY TLPP HCSR GERR AVEK LSVE ALNS LTGE FKGK YYPL KSMT EKEQ QQLI DDHF LFDK PVSP LLLA SGMA RDWP DARG IWHN DNKS FLVW VNEE DHLR VISM EKGG NMKE VFRR FCVG LQKI EEIF KKAG HPFM WNQH LGYV LTCP SNLG TGLR GGVH VKLA HLSK HPKF EEIL TRLR LQKR GTGG VDTA AVGS VFDV SNAD RLGS SEVE QVQL VVDG VKLM VEME KKLE KGQS IDDM IPAQ K |
| Gene ID: | 1158 |
| Uniprot: | P06732 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 43kDa |
| Observed MW: | 43kDa |
| Synonyms: | CKM, CKMM, M-CK |
| Background: | The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. |
| UniProt Protein Function: | CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Kinase, other; EC 2.7.3.2 Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytosol Molecular Function:creatine kinase activity; ATP binding Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P06732 |
| NCBI GenInfo Identifier: | 125305 |
| NCBI Gene ID: | 1158 |
| NCBI Accession: | P06732.2 |
| UniProt Secondary Accession: | P06732,Q96QL9, |
| UniProt Related Accession: | P06732 |
| Molecular Weight: | Calculated: 40kDaObserved: 43kDa |
| NCBI Full Name: | Creatine kinase M-type |
| NCBI Synonym Full Names: | creatine kinase, muscle |
| NCBI Official Symbol: | CKM |
| NCBI Official Synonym Symbols: | CKMM; M-CK |
| NCBI Protein Information: | creatine kinase M-type; creatine kinase M chain |
| UniProt Protein Name: | Creatine kinase M-type |
| UniProt Synonym Protein Names: | Creatine kinase M chain; M-CKCreatine kinase M-type, N-terminally processed |
| Protein Family: | Creatine kinase |
| UniProt Gene Name: | CKM |
| UniProt Entry Name: | KCRM_HUMAN |
 | Western blot analysis of extracts of THP-1 cells, using CKM antibody (CAB2024) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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