Cell Biology Antibodies 7

Anti-CKLF Antibody (CAB16528)

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SKU:
CAB16528
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CKLF Antibody
Antibody SKU:CAB16528
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-67 of human CKLF (NP_057410.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse thymus, Mouse testis, Rat thymus, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-67 of human CKLF (NP_057410.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDNV QPKI KHRP FCFS VKGH VKML RLVF ALVT AVCC LADG ALIY RKLL FNPS GPYQ KKPV HEKK EVL
Gene ID:51192
Uniprot:Q9UBR5
Cellular Location:Membrane, Multi-pass membrane protein, Secreted
Calculated MW:7kDa/10kDa/12kDa/13kDa/17kDa
Observed MW:13kDa
Synonyms:CKLF, C32, CKLF1, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1
Background:The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).
UniProt Protein Function:CKLF: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. Belongs to the chemokine-like factor family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Chemokine; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cell; extracellular region; extracellular space; integral to membrane; membrane

Molecular Function:chemokine activity

Biological Process: cell proliferation; lymphocyte chemotaxis; macrophage chemotaxis; neutrophil chemotaxis; secretion by cell

NCBI Summary:The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]
UniProt Code:Q9UBR5
NCBI GenInfo Identifier:34098753
NCBI Gene ID:51192
NCBI Accession:Q9UBR5.1
UniProt Secondary Accession:Q9UBR5,Q9UHM7, Q9UHN8, Q9UI41, C9JE38,
UniProt Related Accession:Q9UBR5
Molecular Weight:12,888 Da
NCBI Full Name:Chemokine-like factor
NCBI Synonym Full Names:chemokine-like factor
NCBI Official Symbol:CKLF  
NCBI Official Synonym Symbols:C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224  
NCBI Protein Information:chemokine-like factor
UniProt Protein Name:Chemokine-like factor
UniProt Synonym Protein Names:C32
Protein Family:Chemokine-like factor
UniProt Gene Name:CKLF  
UniProt Entry Name:CKLF_HUMAN
Anti-CKLF Antibody (CAB16528)Western blot analysis of extracts of various cell lines, using CKLF antibody (CAB16528) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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