Cell Death Antibodies 2

Anti-CKAP2 Antibody (CAB9706)

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SKU:
CAB9706
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-CKAP2 Antibody
Antibody SKU:CAB9706
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 335-460 of human CKAP2 (NP_001273616.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse spleen, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 335-460 of human CKAP2 (NP_001273616.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EKSE PVDQ RRHT AGKA IVDS RSAQ PKET SEER KARL SEWK AGKG RVLK RPPN SVVT QHEP AGQN EKPV GSFW TTMA EEDE QRLF TEKV NNTF SECL NLIN EGCP KEDI LVTL NDLI KNIP DAKK LV
Gene ID:26586
Uniprot:Q8WWK9
Cellular Location:Cytoplasm, cytoskeleton, spindle, spindle pole
Calculated MW:55kDa/71kDa/76kDa
Observed MW:77kDa
Synonyms:CKAP2, LB1, TMAP, se20-10
Background:This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations.
UniProt Protein Function:CKAP2: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner. Belongs to the CKAP2 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: centrosome; cytoplasm; cytoplasmic microtubule; microtubule cytoskeleton; spindle pole

Biological Process: apoptosis; cytokinesis after mitosis; negative regulation of microtubule depolymerization; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
UniProt Code:Q8WWK9
NCBI GenInfo Identifier:148664201
NCBI Gene ID:26586
NCBI Accession:NP_001091995.1
UniProt Secondary Accession:Q8WWK9,Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012 Q9H0D0, A2BDE0, A5YM58, B4DR35, E9PD90,
UniProt Related Accession:Q8WWK9
Molecular Weight:Calculated MW: 77kDa
NCBI Full Name:cytoskeleton-associated protein 2 isoform 2
NCBI Synonym Full Names:cytoskeleton associated protein 2
NCBI Official Symbol:CKAP2  
NCBI Official Synonym Symbols:LB1; TMAP; se20-10  
NCBI Protein Information:cytoskeleton-associated protein 2
UniProt Protein Name:Cytoskeleton-associated protein 2
UniProt Synonym Protein Names:CTCL tumor antigen se20-10; Tumor- and microtubule-associated protein
Protein Family:Cytoskeleton-associated protein
UniProt Gene Name:CKAP2  
UniProt Entry Name:CKAP2_HUMAN
Anti-CKAP2 Polyclonal Antibody (CAB9706)Western blot analysis of extracts of various cell lines, using CKAP2 antibody (CAB9706) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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