Cell Death Antibodies 2

Anti-CIDEC Antibody (CAB6242)

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SKU:
CAB6242
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-CIDEC Antibody
Antibody SKU:CAB6242
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human CIDEC (NP_001186481.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human CIDEC (NP_001186481.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEYA MKSL SLLY PKSL SRHV SVRT SVVT QQLL SEPS PKAP RARP CRVS TADR SVRK GIMA YSLE DLLL KVRD TLML ADKP FFLV LEED GTTV ETEE YFQA LAGD TVFM VLQK GQKW QPPS EQGT RHPL SLSH KPAK KIDV ARVT FDLY KLNP QDFI GCLN VKAT FYDT YSLS YDLH CCGA KRIM KEAF RWAL FSMQ ATGH VLLG TSCY LQQL LDAT EEGQ PPKG KASS LIPT CLKI LQ
Gene ID:63924
Uniprot:Q96AQ7
Cellular Location:Endoplasmic reticulum, Lipid droplet, Nucleus
Calculated MW:14kDa/18kDa/26kDa/27kDa
Observed MW:Refer to figures
Synonyms:CIDEC, CIDE-3, CIDE3, FPLD5, FSP27
Background:This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
UniProt Protein Function:CIDEC: May act as a CEBPB coactivator in white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. In omental adipose tissue of obese patients matched for BMI, expression levels tend to correlate with insulin sensitivity. Expression is increased 2-3 fold in the group of patients with high insulin sensitivity, compared to the insulin- resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. This effect is not significant in subcutaneous adipose tissue (PubMed:18509062). In subcutaneous adipose tissue of diabetic patients, tends to negatively correlate with body mass index and total fat mass, independently of insulin sensitivity (PubMed:18334488). 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: endoplasmic reticulum; lipid particle; cytosol; nucleus

Biological Process: regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis

Disease: Lipodystrophy, Familial Partial, Type 5

NCBI Summary:This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q96AQ7
NCBI GenInfo Identifier:20138281
NCBI Gene ID:63924
NCBI Accession:Q96AQ7.1
UniProt Secondary Accession:Q96AQ7,Q67DW9, Q9GZY9, C9JMN7,
UniProt Related Accession:Q96AQ7
Molecular Weight:238
NCBI Full Name:Cell death activator CIDE-3
NCBI Synonym Full Names:cell death-inducing DFFA-like effector c
NCBI Official Symbol:CIDEC  
NCBI Official Synonym Symbols:CIDE3; FPLD5; FSP27; CIDE-3  
NCBI Protein Information:cell death activator CIDE-3; fat specific protein 27
UniProt Protein Name:Cell death activator CIDE-3
UniProt Synonym Protein Names:Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27 homolog
Protein Family:Cell death activator
UniProt Gene Name:CIDEC  
UniProt Entry Name:CIDEC_HUMAN
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