Signal Transduction Antibodies 3

Anti-CHRNA6 Antibody (CAB8470)

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SKU:
CAB8470
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CHRNA6 Antibody
Antibody SKU:CAB8470
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PQVL LMRW PLDK TRGT GSDA VPRG LARR PAKG KLAS HGEP RHLK ECFH CHKS NELA TSKR RLSH QPLQ WVVE NSEH SPEV EDVI NSVQ FIA
Gene ID:8973
Uniprot:Q15825
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:55kDa/56kDa
Observed MW:57kDa
Synonyms:CHRNA6, CHNRA6
Background:This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence.
UniProt Protein Function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
NCBI Summary:This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]
UniProt Code:Q15825
NCBI GenInfo Identifier:313482792
NCBI Gene ID:8973
NCBI Accession:NP_001186208.1
UniProt Secondary Accession:Q15825,B2R8V4, B4DQH1,
UniProt Related Accession:Q15825
Molecular Weight:54
NCBI Full Name:neuronal acetylcholine receptor subunit alpha-6 isoform 2
NCBI Synonym Full Names:cholinergic receptor nicotinic alpha 6 subunit
NCBI Official Symbol:CHRNA6  
NCBI Official Synonym Symbols:CHNRA6  
NCBI Protein Information:neuronal acetylcholine receptor subunit alpha-6
UniProt Protein Name:Neuronal acetylcholine receptor subunit alpha-6
UniProt Gene Name:CHRNA6  
Anti-CHRNA6 Polyclonal Antibody (CAB8470)Western blot analysis of extracts of various cell lines, using CHRNA6 antibody (CAB8470) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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