Signal Transduction Antibodies 1
Anti-CHRNA6 Antibody (CAB14081)
- SKU:
- CAB14081
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-CHRNA6 Antibody |
Antibody SKU: | CAB14081 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Rat |
Positive Samples: | Raji, Rat liver |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | PQVL LMRW PLDK TRGT GSDA VPRG LARR PAKG KLAS HGEP RHLK ECFH CHKS NELA TSKR RLSH QPLQ WVVE NSEH SPEV EDVI NSVQ FIA |
Gene ID: | 8973 |
Uniprot: | Q15825 |
Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
Calculated MW: | 55kDa/56kDa |
Observed MW: | 57kDa |
Synonyms: | CHRNA6, CHNRA6 |
Background: | This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. |
UniProt Protein Function: | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
NCBI Summary: | This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q15825 |
NCBI GenInfo Identifier: | 313482792 |
NCBI Gene ID: | 8973 |
NCBI Accession: | NP_001186208.1 |
UniProt Secondary Accession: | Q15825,B2R8V4, B4DQH1, |
UniProt Related Accession: | Q15825 |
Molecular Weight: | 54 |
NCBI Full Name: | neuronal acetylcholine receptor subunit alpha-6 isoform 2 |
NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 6 subunit |
NCBI Official Symbol: | CHRNA6 |
NCBI Official Synonym Symbols: | CHNRA6 |
NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-6 |
UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-6 |
UniProt Gene Name: | CHRNA6 |
View AllClose