Signal Transduction Antibodies 2
Anti-CHRNA5 Antibody (CAB1741)
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- SKU:
- CAB1741
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CHRNA5 Antibody |
| Antibody SKU: | CAB1741 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-240 of human CHRNA5 (NP_000736.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, U-251MG, Jurkat, MCF-7, Mouse brain, Mouse stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-240 of human CHRNA5 (NP_000736.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RCGL AGAA GGAQ RGLS EPSS IAKH EDSL LKDL FQDY ERWV RPVE HLND KIKI KFGL AISQ LVDV DEKN QLMT TNVW LKQE WIDV KLRW NPDD YGGI KVIR VPSD SVWT PDIV LFDN ADGR FEGT STKT VIRY NGTV TWTP PANY KSSC TIDV TFFP FDLQ NCSM KFGS WTYD GSQV DIIL EDQD VDKR DFFD NGEW EIVS ATGS KGNR TDSC CWYP YV |
| Gene ID: | 1138 |
| Uniprot: | P30532 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 53kDa |
| Observed MW: | 50kDa |
| Synonyms: | CHRNA5, LNCR2 |
| Background: | The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2). |
| UniProt Protein Function: | nAChRA5: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24 Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction Molecular Function:acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity Biological Process: synaptic transmission; transport; behavioral response to nicotine; signal transduction; cation transport Disease: Smoking As A Quantitative Trait Locus 3 |
| NCBI Summary: | The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010] |
| UniProt Code: | P30532 |
| NCBI GenInfo Identifier: | 2506126 |
| NCBI Gene ID: | 1138 |
| NCBI Accession: | P30532.2 |
| UniProt Related Accession: | P30532 |
| Molecular Weight: | Molecular Mass: 27.6kDaActual Protein Molecular Mass: 35-40kDa |
| NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-5 |
| NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 5 subunit |
| NCBI Official Symbol: | CHRNA5 |
| NCBI Official Synonym Symbols: | LNCR2 |
| NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-5 |
| UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-5 |
| Protein Family: | Neuronal acetylcholine receptor |
| UniProt Gene Name: | CHRNA5 |
| UniProt Entry Name: | ACHA5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CHRNA5 antibody (CAB1741) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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