Cell Biology Antibodies 8

Anti-CHRNA10 Antibody (CAB3042)

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SKU:
CAB3042
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CHRNA10 Antibody
Antibody SKU:CAB3042
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human
Positive Samples:HL-60, U2OS
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AEGR LALK LFRD LFAN YTSA LRPV ADTD QTLN VTLE VTLS QIID MDER NQVL TLYL WIRQ EWTD AYLR WDPN AYGG LDAI RIPS SLVW RPDI VLYN KADA QPPG SAST NVVL RHDG AVRW DAPA ITRS SCRV DVAA FPFD AQHC GLTF GSWT HGGH QLDV RPRG AAAS LADF VENV EWRV LGMP ARRR VLTY GCCS EPYP DVTF TLLL RRRA AAYV
Gene ID:57053
Uniprot:Q9GZZ6
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:49kDa
Observed MW:45kDa
Synonyms:CHRNA10
Background:
UniProt Protein Function:nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily.
UniProt Protein Details:

Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; nicotinic acetylcholine-gated receptor-channel complex

Molecular Function:acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; regulation of cell proliferation; synaptic transmission, cholinergic

UniProt Code:Q9GZZ6
NCBI GenInfo Identifier:14916526
NCBI Gene ID:57053
NCBI Accession:Q9GZZ6.1
UniProt Related Accession:Q9GZZ6
Molecular Weight:49,705 Da
NCBI Full Name:Neuronal acetylcholine receptor subunit alpha-10
NCBI Synonym Full Names:cholinergic receptor nicotinic alpha 10 subunit
NCBI Official Symbol:CHRNA10  
NCBI Protein Information:neuronal acetylcholine receptor subunit alpha-10
UniProt Protein Name:Neuronal acetylcholine receptor subunit alpha-10
UniProt Synonym Protein Names:Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10
Protein Family:Neuronal acetylcholine receptor
UniProt Gene Name:CHRNA10  
UniProt Entry Name:ACH10_HUMAN
Anti-CHRNA10 Antibody (CAB3042)Western blot analysis of extracts of various cell lines, using CHRNA10 antibody (CAB3042) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
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