Cell Biology Antibodies 6

Anti-CHRM5 Antibody (CAB16293)

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SKU:
CAB16293
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CHRM5 Antibody
Antibody SKU:CAB16293
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-430 of human CHRM5 (NP_036257.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-430 of human CHRM5 (NP_036257.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LQGS DSVT KAEK RKPA HRAL FRSC LRCP RPTL AQRE RNQA SWSS SRRS TSTT GKPS QATG PSAN WAKA EQLT TCSS YPSS EDED KPAT DPVL QVVY KSQG KESP GEEF SAEE TEET FVKA ETEK SDYD TPNY LLSP AAAH RPKS QKCV AYKF RLVV KADG NQET NNGC HKVK IMPC PFPV AKEP STKG LNPN PSHQ MTKR K
Gene ID:1133
Uniprot:P08912
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:60kDa
Observed MW:Refer to figures
Synonyms:CHRM5, HM5
Background:The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels.
UniProt Protein Function:mAChR M5: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
UniProt Protein Details:

Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function:phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity

Biological Process: dopamine transport; gastric acid secretion; cell proliferation; acetylcholine receptor signaling, muscarinic pathway; metabolic process; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; transmission of nerve impulse

NCBI Summary:The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
UniProt Code:P08912
NCBI GenInfo Identifier:543761
NCBI Gene ID:1133
NCBI Accession:P08912.2
UniProt Secondary Accession:P08912,Q96RG7,
UniProt Related Accession:P08912
Molecular Weight:532
NCBI Full Name:Muscarinic acetylcholine receptor M5
NCBI Synonym Full Names:cholinergic receptor, muscarinic 5
NCBI Official Symbol:CHRM5  
NCBI Official Synonym Symbols:HM5  
NCBI Protein Information:muscarinic acetylcholine receptor M5; acetylcholine receptor, muscarinic 5
UniProt Protein Name:Muscarinic acetylcholine receptor M5
Protein Family:Muscarinic acetylcholine receptor
UniProt Gene Name:CHRM5  
UniProt Entry Name:ACM5_HUMAN
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