Cell Biology Antibodies 8

Anti-CHRM4 Antibody (CAB2866)

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SKU:
CAB2866
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CHRM4 Antibody
Antibody SKU:CAB2866
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CHRM4
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:NIH/3T3
Immunogen:A synthetic peptide of human CHRM4
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1132
Uniprot:P08173
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:53kDa
Observed MW:53kDa
Synonyms:CHRM4, HM4, M4R
Background:The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition.
UniProt Protein Function:mAChR M4: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 11p12-p11.2

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function:G-protein coupled acetylcholine receptor activity

Biological Process: regulation of locomotion; cell proliferation; acetylcholine receptor signaling, muscarinic pathway; cell surface receptor linked signal transduction; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; signal transduction

NCBI Summary:The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
UniProt Code:P08173
NCBI GenInfo Identifier:23503039
NCBI Gene ID:1132
NCBI Accession:P08173.2
UniProt Secondary Accession:P08173,Q0VD60, Q4VBK7, B2RPP4,
UniProt Related Accession:P08173
Molecular Weight:479
NCBI Full Name:Muscarinic acetylcholine receptor M4
NCBI Synonym Full Names:cholinergic receptor, muscarinic 4
NCBI Official Symbol:CHRM4  
NCBI Official Synonym Symbols:HM4; M4R  
NCBI Protein Information:muscarinic acetylcholine receptor M4; acetylcholine receptor, muscarinic 4
UniProt Protein Name:Muscarinic acetylcholine receptor M4
Protein Family:Muscarinic acetylcholine receptor
UniProt Gene Name:CHRM4  
UniProt Entry Name:ACM4_HUMAN
Anti-CHRM4 Antibody (CAB2866)Western blot analysis of extracts of NIH/3T3 cells, using CHRM4 antibody (CAB2866). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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