Antibody Name:	Anti-CHRFAM7A Antibody
Antibody SKU:	CAB7844
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CHRFAM7A (NP_647536.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	A-549, Jurkat, SH-SY5Y, U-87MG, NIH/3T3, Mouse brain, Mouse spinal cord, Rat brain, Rat spinal cord

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CHRFAM7A (NP_647536.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MQKY CIYQ HFQF QLLI QHLW IAAN CDIA DERF DATF HTNV LVNS SGHC QYLP PGIF KSSC YIDV RWFP FDVQ HCKL KFGS WSYG GWSL DLQM QEAD ISGY IPNG EWDL VGIP GKRS ERFY ECCK EPYP DVTF TVTM RRRT LYYG LNLL IP
Gene ID:	89832
Uniprot:	Q494W8
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	46kDa
Observed MW:	46kDa

Synonyms:

CHRFAM7A, CHRNA7, CHRNA7-DR1, D-10

Background:

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

UniProt Protein Function:	CHRFAM7A: Belongs to the ligand-gated ion channel (TC 1.A.9) family
UniProt Protein Details:	Protein type:Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q13.1 Cellular Component: integral to membrane Molecular Function:extracellular ligand-gated ion channel activity
NCBI Summary:	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]
UniProt Code:	Q494W8
NCBI GenInfo Identifier:	91208254
NCBI Gene ID:	89832
NCBI Accession:	Q494W8.1
UniProt Related Accession:	Q494W8
Molecular Weight:	46kDa
NCBI Full Name:	CHRNA7-FAM7A fusion protein
NCBI Synonym Full Names:	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
NCBI Official Symbol:	CHRFAM7A
NCBI Official Synonym Symbols:	D-10; CHRNA7; NACHRA7; CHRNA7-DR1
NCBI Protein Information:	CHRNA7-FAM7A fusion protein
UniProt Protein Name:	CHRNA7-FAM7A fusion protein
UniProt Synonym Protein Names:	CHRNA7-DR1; D-10
Protein Family:	CHRNA7-FAM7A fusion protein
UniProt Gene Name:	CHRFAM7A
UniProt Entry Name:	CRFM7_HUMAN

	Immunohistochemistry of paraffin-embedded human prostate using CHRFAM7A antibody (CAB7844) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using CHRFAM7A antibody (CAB7844) at dilution of 1:100 (40x lens).