Cell Biology Antibodies 13
Anti-CHRD Antibody (CAB17571)
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- SKU:
- CAB17571
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CHRD Antibody |
| Antibody SKU: | CAB17571 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 686-955 of human CHRD (NP_003732.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 686-955 of human CHRD (NP_003732.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PALA PAKP GGPG RPRD PNTC FFEG QQRP HGAR WAPN YDPL CSLC TCQR RTVI CDPV VCPP PSCP HPVQ APDQ CCPV CPEK QDVR DLPG LPRS RDPG EGCY FDGD RSWR AAGT RWHP VVPP FGLI KCAV CTCK GGTG EVHC EKVQ CPRL ACAQ PVRV NPTD CCKQ CPVG SGAH PQLG DPMQ ADGP RGCR FAGQ WFPE SQSW HPSV PPFG EMSC ITCR CGAG VPHC ERDD CSLP LSCG SGKE SRCC SRCT AHRR PAPE TRTD PELE KEAE GS |
| Gene ID: | 8646 |
| Uniprot: | Q9H2X0 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 102kDa |
 | Western blot - CHRD Polyclonal Antibody (CAB17571) |
| Synonyms: | CHRD |
| Background: | This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015] |
| UniProt Protein Function: | CHRD: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Belongs to the chordin family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q27 Molecular Function:protein binding Biological Process: BMP signaling pathway in spinal cord dorsal-ventral patterning; floor plate development; negative regulation of BMP signaling pathway; negative regulation of cell migration; negative regulation of osteoblast differentiation; positive regulation of cell adhesion; positive regulation of mesenchymal cell proliferation; skeletal development |
| NCBI Summary: | This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q9H2X0 |
| NCBI GenInfo Identifier: | 118572631 |
| NCBI Gene ID: | 8646 |
| NCBI Accession: | Q9H2X0.2 |
| UniProt Secondary Accession: | Q9H2X0,O95254, Q2M1I8, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9 Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5, |
| UniProt Related Accession: | Q9H2X0 |
| Molecular Weight: | 97,731 Da |
| NCBI Full Name: | Chordin |
| NCBI Synonym Full Names: | chordin |
| NCBI Official Symbol: | CHRD |
| NCBI Protein Information: | chordin |
| UniProt Protein Name: | Chordin |
| Protein Family: | Chordin |
| UniProt Gene Name: | CHRD |
| UniProt Entry Name: | CHRD_HUMAN |
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