UniProt Protein Function: | CHORDC1: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 11q14.3 Molecular Function:protein binding; zinc ion binding; Hsp90 protein binding |
UniProt Code: | Q9UHD1 |
NCBI GenInfo Identifier: | 221316570 |
NCBI Gene ID: | 26973 |
NCBI Accession: | NP_001137545.1 |
UniProt Secondary Accession: | Q9UHD1,Q6IN49, Q8WVL9, Q9H3D6, B2R6P8, |
UniProt Related Accession: | Q9UHD1 |
Molecular Weight: | 37490 |
NCBI Full Name: | cysteine and histidine-rich domain-containing protein 1 isoform b |
NCBI Synonym Full Names: | cysteine and histidine-rich domain (CHORD) containing 1 |
NCBI Official Symbol: | CHORDC1 |
NCBI Official Synonym Symbols: | CHP1 |
NCBI Protein Information: | cysteine and histidine-rich domain-containing protein 1 |
UniProt Protein Name: | Cysteine and histidine-rich domain-containing protein 1 |
UniProt Synonym Protein Names: | CHORD domain-containing protein 1; CHORD-containing protein 1; CHP-1; Protein morgana |
Protein Family: | Cysteine and histidine-rich domain-containing protein |
UniProt Gene Name: | CHORDC1 |
UniProt Entry Name: | CHRD1_HUMAN |