Neuroscience
Anti-CHN1 Antibody (CAB7546)
- SKU:
- CAB7546
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-CHN1 Antibody |
| Antibody SKU: | CAB7546 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN1 (NP_001813.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, SH-SY5Y, Jurkat, HeLa, MCF7, Mouse testis, Mouse brain, Mouse spinal cord, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN1 (NP_001813.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MALT LFDT DEYR PPVW KSYL YQLQ QEAP HPRR ITCT CEVE NRPK YYGR EFHG MISR EAAD QLLI VAEG SYLI RESQ RQPG TYTL ALRF GSQT RNFR LYYD GKHF VGEK RFES IHDL VTDG LITL YIET KAAE YIAK MTIN PIYE HVGY TTLN REPA YKKH MPVL KETH DERD STGQ DGVS EKRL TSLV RRAT LKEN EQIP |
| Gene ID: | 1123 |
| Uniprot: | P15882 |
| Cellular Location: | |
| Calculated MW: | 38kDa/50kDa/53kDa |
| Observed MW: | 53kDa |
| Synonyms: | CHN1, ARHGAP2, CHN, DURS2, NC, RHOGAP2 |
| Background: | This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; Adaptor/scaffold; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: cytosol Molecular Function:SH3/SH2 adaptor activity; ephrin receptor binding; metal ion binding; GTPase activator activity Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; ephrin receptor signaling pathway; motor axon guidance; regulation of axonogenesis; positive regulation of GTPase activity Disease: Duane Retraction Syndrome 2 |
| NCBI Summary: | This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | P15882 |
| NCBI GenInfo Identifier: | 21903393 |
| NCBI Gene ID: | 1123 |
| NCBI Accession: | P15882.3 |
| UniProt Related Accession: | P15882 |
| Molecular Weight: | |
| NCBI Full Name: | N-chimaerin |
| NCBI Synonym Full Names: | chimerin 1 |
| NCBI Official Symbol: | CHN1 |
| NCBI Official Synonym Symbols: | NC; CHN; DURS2; ARHGAP2; RHOGAP2 |
| NCBI Protein Information: | N-chimaerin |
| UniProt Protein Name: | N-chimaerin |
| UniProt Synonym Protein Names: | A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2 |
| Protein Family: | N-chimaerin |
| UniProt Gene Name: | CHN1 |
| UniProt Entry Name: | CHIN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CHN1 antibody (CAB7546) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CHN1 antibody (CAB7546) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using CHN1 antibody (CAB7546) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using CHN1 antibody (CAB7546) at dilution of 1:100 (40x lens). |
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