Anti-CHMP6 Antibody (CAB4975)

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SKU:
CAB4975
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CHMP6
Synonyms:
VPS20

Description

Product Name:CHMP6 Rabbit pAb
Product Code:CAB4975
Size:100uL
Synonyms:CHMP6, VPS20
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic Peptide of human CHMP6
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:1000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:U2OS, PC-3, Jurkat
Immunogen:A synthetic Peptide of human CHMP6
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:79643
Uniprot:Q96FZ7
Cellular Location:Endomembrane system, Endosome membrane, Late endosome membrane, Lipid-anchor, Membrane
Calculated MW:23kDa
Observed MW:30kDa
UniProt Protein Function:CHMP6: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. Belongs to the SNF7 family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: membrane; late endosome membrane; cytosol

Molecular Function:protein binding; protein N-terminus binding

Biological Process: protein transport; cell separation during cytokinesis; viral reproduction; vacuolar transport; viral infectious cycle; endosome transport; mitotic metaphase plate congression; nuclear organization and biogenesis

NCBI Summary:This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]
UniProt Code:Q96FZ7
NCBI GenInfo Identifier:73917777
NCBI Gene ID:79643
NCBI Accession:Q96FZ7.3
UniProt Related Accession:Q96FZ7
Molecular Weight:
NCBI Full Name:Charged multivesicular body protein 6
NCBI Synonym Full Names:charged multivesicular body protein 6
NCBI Official Symbol:CHMP6  
NCBI Official Synonym Symbols:VPS20  
NCBI Protein Information:charged multivesicular body protein 6
UniProt Protein Name:Charged multivesicular body protein 6
UniProt Synonym Protein Names:Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20
Protein Family:Charged multivesicular body protein
UniProt Gene Name:CHMP6  
UniProt Entry Name:CHMP6_HUMAN
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