Cell Cycle Antibodies 2
Anti-CHMP1B Antibody (CAB8239)
- SKU:
- CAB8239
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Antibody Name: | CHMP1B Rabbit Polyclonal Antibody |
Antibody SKU: | CAB8239 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human CHMP1B (NP_065145.2). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | NCI-H460, MCF7, SKOV3, U-251MG, Mouse liver, Mouse spleen, Mouse brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human CHMP1B (NP_065145.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MSNM EKHL FNLK FAAK ELSR SAKK CDKE EKAE KAKI KKAI QKGN MEVA RIHA ENAI RQKN QAVN FLRM SARV DAVA ARVQ TAVT MGKV TKSM AGVV KSMD ATLK TMNL EKIS ALMD KFEH QFET LDVQ TQQM EDTM SSTT TLTT PQNQ VDML LQEM ADEA GLDL NMEL PQGQ TGSV GTSV ASAE QDEL SQRL ARLR DQV |
Gene ID: | 57132 |
Uniprot: | Q7LBR1 |
Cellular Location: | Cytoplasm, Endosome, Late endosome membrane, Peripheral membrane protein, cytosol |
Calculated MW: | 22kDa |
Observed MW: | 30kDa |
Synonyms: | CHMP1B, C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2 |
Background: |
UniProt Protein Function: | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. |
NCBI Summary: | CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q7LBR1 |
NCBI GenInfo Identifier: | 31542306 |
NCBI Gene ID: | 57132 |
NCBI Accession: | NP_065145 |
UniProt Secondary Accession: | Q7LBR1,Q96E89, Q9HD41, |
UniProt Related Accession: | Q7LBR1 |
Molecular Weight: | 24.7 kDa (223aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher) |
NCBI Full Name: | charged multivesicular body protein 1b |
NCBI Synonym Full Names: | charged multivesicular body protein 1B |
NCBI Official Symbol: | CHMP1B |
NCBI Official Synonym Symbols: | Vps46B; C10orf2; C18orf2; CHMP1.5; Vps46-2; C18-ORF2; hVps46-2 |
NCBI Protein Information: | charged multivesicular body protein 1b |
UniProt Protein Name: | Charged multivesicular body protein 1b |
UniProt Synonym Protein Names: | CHMP1.5; Chromatin-modifying protein 1b; CHMP1b; Vacuolar protein sorting-associated protein 46-2; Vps46-2; hVps46-2 |
Protein Family: | Charged multivesicular body protein |
UniProt Gene Name: | CHMP1B |
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