Cell Death Antibodies 1

Anti-CHIA Antibody (CAB3416)

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SKU:
CAB3416
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-CHIA Antibody
Antibody SKU:CAB3416
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CHIA (NP_001244932.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse stomach, Rat stomach
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CHIA (NP_001244932.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVST PENR QTFI TSVI KFLR QYEF DGLD FDWE YPGS RGSP PQDK HLFT VLVQ EMRE AFEQ EAKQ INKP RLMV TAAV AAGI SNIQ SGYE IPQL SQYL DYIH VMTY DLHG SWEG YTGE NSPL YKYP TDTG SNAY LNVD YVMN YWKD NGAP AEKL IVGF PTYG HNFI LSNP SNTG IGAP TSGA GPAG PYAK ESGI WAYY EICT FLKN GATQ GWDA PQEV PYAY QGNV WVGY DNIK SFDI KAQW LKHN KFGG AMVW AIDL DDFT GTFC NQGK FPLI STLK KALG LQSA SCTA PAQP IEPI TAAP SGSG NGSG SSSS GGSS GGSG FCAV RANG LYPV ANNR NAFW HCVN GVTY QQNC QAGL VFDT SCDC CNWA
Gene ID:27159
Uniprot:Q9BZP6
Cellular Location:Cytoplasm, Secreted
Calculated MW:33kDa/40kDa/52kDa
Observed MW:52kDa
Synonyms:CHIA, AMCASE, CHIT2, TSA1902, chitinase, acidic
Background:The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene.
UniProt Protein Function:CHIA: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Secreted, signal peptide; Secreted; EC 3.2.1.14

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: extracellular space; cytoplasm

Molecular Function:lysozyme activity; chitin binding; chitinase activity; carbohydrate binding; kinase binding

Biological Process: response to fungus; polysaccharide catabolic process; apoptosis; production of molecular mediator of acute inflammatory response; cell wall chitin metabolic process; digestion; immune response; chitin catabolic process; chitin metabolic process

NCBI Summary:The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:Q9BZP6
NCBI GenInfo Identifier:37999771
NCBI Gene ID:27159
NCBI Accession:Q9BZP6.1
UniProt Secondary Accession:Q9BZP6,Q32W79, Q32W80, Q3B866, Q5U5Z5, Q5VUV4, Q86UD8 Q9ULY3, Q9ULY4,
UniProt Related Accession:Q9BZP6
Molecular Weight:476
NCBI Full Name:Acidic mammalian chitinase
NCBI Synonym Full Names:chitinase, acidic
NCBI Official Symbol:CHIA  
NCBI Official Synonym Symbols:CHIT2; AMCASE; TSA1902  
NCBI Protein Information:acidic mammalian chitinase; lung-specific protein TSA1902
UniProt Protein Name:Acidic mammalian chitinase
UniProt Synonym Protein Names:Lung-specific protein TSA1902
Protein Family:Chitinase
UniProt Gene Name:CHIA  
UniProt Entry Name:CHIA_HUMAN
Anti-CHIA Antibody (CAB3416)Western blot analysis of extracts of various cell lines, using CHIA antibody (CAB3416) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-CHIA Antibody (CAB3416)Immunohistochemistry of paraffin-embedded human esophageal cancer using CHIA antibody (CAB3416) at dilution of 1:100 (40x lens).
Anti-CHIA Antibody (CAB3416)Immunohistochemistry of paraffin-embedded human gastric cancer using CHIA antibody (CAB3416) at dilution of 1:100 (40x lens).
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