Cell Biology Antibodies 11
Anti-CHI3L2 Antibody (CAB7654)
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- SKU:
- CAB7654
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CHI3L2 Antibody |
| Antibody SKU: | CAB7654 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-390 of human CHI3L2 (NP_003991.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Mouse spinal cord, Rat spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-390 of human CHI3L2 (NP_003991.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YKLV CYFT NWSQ DRQE PGKF TPEN IDPF LCSH LIYS FASI ENNK VIIK DKSE VMLY QTIN SLKT KNPK LKIL LSIG GYLF GSKG FHPM VDSS TSRL EFIN SIIL FLRN HNFD GLDV SWIY PDQK ENTH FTVL IHEL AEAF QKDF TKST KERL LLTA GVSA GRQM IDNS YQVE KLAK DLDF INLL SFDF HGSW EKPL ITGH NSPL SKGW QDRG PSSY YNVE YAVG YWIH KGMP SEKV VMGI PTYG HSFT LASA ETTV GAPA SGPG AAGP ITES SGFL AYYE ICQF LKGA KITR LQDQ QVPY AVKG NQWV GYDD VKSM ETKV QFLK NLNL GGAM IWSI DMDD FTGK SCNQ GPYP LVQA VKRS LGSL |
| Gene ID: | 1117 |
| Uniprot: | Q15782 |
| Cellular Location: | Secreted |
| Calculated MW: | 34kDa/42kDa/43kDa |
| Observed MW: | 44kDa |
| Synonyms: | CHI3L2, CHIL2, YKL-39, YKL39 |
| Background: | The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CHI3L2: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: extracellular space Molecular Function:chitin binding; chitinase activity Biological Process: chitin catabolic process |
| NCBI Summary: | The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q15782 |
| NCBI GenInfo Identifier: | 13124005 |
| NCBI Gene ID: | 1117 |
| NCBI Accession: | Q15782.1 |
| UniProt Secondary Accession: | Q15782,Q15749, Q15783, Q5VUV7, Q96F97, A6NNY3, B4DPR7 |
| UniProt Related Accession: | Q15782 |
| Molecular Weight: | 42,508 Da |
| NCBI Full Name: | Chitinase-3-like protein 2 |
| NCBI Synonym Full Names: | chitinase 3 like 2 |
| NCBI Official Symbol: | CHI3L2 |
| NCBI Official Synonym Symbols: | CHIL2; YKL39; YKL-39 |
| NCBI Protein Information: | chitinase-3-like protein 2 |
| UniProt Protein Name: | Chitinase-3-like protein 2 |
| UniProt Synonym Protein Names: | Chondrocyte protein 39; YKL-39 |
| Protein Family: | Chitinase-3-like protein |
| UniProt Gene Name: | CHI3L2 |
| UniProt Entry Name: | CH3L2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CHI3L2 antibody (CAB7654) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat lung using CHI3L2 antibody (CAB7654) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using CHI3L2 antibody (CAB7654) at dilution of 1:100 (40x lens). |
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