Cell Biology Antibodies 8

Anti-CHGB Antibody (CAB2864)

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SKU:
CAB2864
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CHGB Antibody
Antibody SKU:CAB2864
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CHGB (NP_001810.2).
Application:WB
Recommended Dilution:WB 1:100 - 1:500
Reactivity:Human, Mouse
Positive Samples:NCI-H460, SW620, HT-1080, Mouse eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CHGB (NP_001810.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQPT LLLS LLGA VGLA AVNS MPVD NRNH NEGM VTRC IIEV LSNA LSKS SAPP ITPE CRQV LKTS RKDV KDKE TTEN ENTK FEVR LLRD PADA SEAH ESSS RGEA GAPG EEDI QGPT KADT EKWA EGGG HSRE RADE PQWS LYPS DSQV SEEV KTRH SEKS QRED EEEE EGEN YQKG ERGE DSSE EKHL EEPG ETQN AFLN ERKQ ASAI KKEE LVAR SETH AAGH SQEK THSR EKSS QESG EETG SQEN HPQE SKGQ PRSQ EESE EGEE DATS EVDK RRTR PRHH HGRS RPDR SSQG GSLP
Gene ID:1114
Uniprot:P05060
Cellular Location:Secreted
Calculated MW:78kDa
Observed MW:110kDa
Synonyms:CHGB, SCG1
Background:This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides.
UniProt Protein Function:CHGB: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: extracellular region; secretory granule

Molecular Function:protein binding; hormone activity

NCBI Summary:This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
UniProt Code:P05060
NCBI GenInfo Identifier:311033509
NCBI Gene ID:1114
NCBI Accession:P05060.2
UniProt Secondary Accession:P05060,Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6, A8K021
UniProt Related Accession:P05060
Molecular Weight:78kDa
NCBI Full Name:Secretogranin-1
NCBI Synonym Full Names:chromogranin B (secretogranin 1)
NCBI Official Symbol:CHGB  
NCBI Official Synonym Symbols:SCG1  
NCBI Protein Information:secretogranin-1; cgB; sgI; chromogranin-B; secretogranin B; secretogranin I
UniProt Protein Name:Secretogranin-1
UniProt Synonym Protein Names:Chromogranin-B; CgB; Secretogranin I; SgI
Protein Family:Secretogranin
UniProt Gene Name:CHGB  
UniProt Entry Name:SCG1_HUMAN
Anti-CHGB Antibody (CAB2864)Western blot analysis of extracts of various cell lines, using CHGB antibody (CAB2864) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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