| Background: | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CHGA: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells and is a precursor to multiple biologically active peptides including vasostatin, pancreastatin, and chromostatin. Binds calcium with a low-affinity. Vasostatin negatively regulates angiogenesis and has antibacterial activity against some Gram-positive bacteria. Pancreastatin inhibits glucose induced insulin release from the pancreas. Chromostatin inhibits catecholamine release from chromaffin cells. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Vesicle; Cell adhesion Chromosomal Location of Human Ortholog: 14q32 Cellular Component: extracellular space; perinuclear region of cytoplasm; secretory granule Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; mast cell activation; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; negative regulation of catecholamine secretion; negative regulation of vasodilation; organelle organization and biogenesis; positive regulation of cAMP metabolic process; regulation of blood pressure; regulation of the force of heart contraction |
| NCBI Summary: | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P10645 |
| NCBI GenInfo Identifier: | 215274270 |
| NCBI Gene ID: | 1113 |
| NCBI Accession: | P10645.7 |
| UniProt Secondary Accession: | P10645,Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5, B2R9E9 |
| UniProt Related Accession: | P10645 |
| Molecular Weight: | 50,688 Da |
| NCBI Full Name: | Chromogranin-A |
| NCBI Synonym Full Names: | chromogranin A |
| NCBI Official Symbol: | CHGA |
| NCBI Official Synonym Symbols: | CGA |
| NCBI Protein Information: | chromogranin-A |
| UniProt Protein Name: | Chromogranin-A |
| UniProt Synonym Protein Names: | SL21 |
| Protein Family: | Chromogranin |
| UniProt Gene Name: | CHGA |
| UniProt Entry Name: | CMGA_HUMAN |
![CHGA Monoclonal Antibody [P3A5AT] (CPAB0534)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58755/63937/chga-monoclonal-antibody-p3a5at-cpab0534__09273__82963.1706535207.jpg?c=1 "CHGA Monoclonal Antibody [P3A5AT] (CPAB0534)")
