Signal Transduction Antibodies 1
Anti-CGB Antibody (CAB12419)
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- SKU:
- CAB12419
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CGB Antibody |
| Antibody SKU: | CAB12419 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-165 of human CGB (NP_000728.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-165 of human CGB (NP_000728.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SKEP LRPR CRPI NATL AVEK EGCP VCIT VNTT ICAG YCPT MTRV LQGV LPAL PQVV CNYR DVRF ESIR LPGC PRGV NPVV SYAV ALSC QCAL CRRS TTDC GGPK DHPL TCDD PRFQ DSSS SKAP PPSL PSPS RLPG PSDT PILP Q |
| Gene ID: | 1082 |
| Uniprot: | P0DN86 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | CGB3, CGB, CGB5, CGB7, CGB8, hCGB |
| Background: | This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. |
| UniProt Protein Function: | Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. |
| NCBI Summary: | This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P0DN86 |
| NCBI GenInfo Identifier: | 1027923599 |
| NCBI Gene ID: | 1082 |
| NCBI Accession: | P0DN86.1 |
| UniProt Related Accession: | P0DN86 |
| Molecular Weight: | |
| NCBI Full Name: | Choriogonadotropin subunit beta 3 |
| NCBI Synonym Full Names: | chorionic gonadotropin subunit beta 3 |
| NCBI Official Symbol: | CGB3 |
| NCBI Official Synonym Symbols: | CGB; CGB5; CGB7; CGB8; hCGB |
| NCBI Protein Information: | choriogonadotropin subunit beta 3 |
| UniProt Protein Name: | Choriogonadotropin subunit beta 3 |
| UniProt Synonym Protein Names: | Choriogonadotropin subunit beta; CG-beta; Chorionic gonadotropin chain beta |
| UniProt Gene Name: | CGB3 |
 | Western blot analysis of extracts of MCF7 cells, using CGB Rabbit pAb (CAB12419) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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