Cell Biology Antibodies 15

Anti-cGAS Antibody (CAB8335)

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SKU:
CAB8335
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody

Description

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Antibody Name:Anti-cGAS Antibody
Antibody SKU:CAB8335
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-522 of human cGAS (NP_612450.2).
Application:WB IHC IF IP
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, DU145, MCF7, U-251MG, HeLa, Mouse brain, Mouse heart, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-522 of human cGAS (NP_612450.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KQLR LKPF YLVP KHAK EGNG FQEE TWRL SFSH IEKE ILNN HGKS KTCC ENKE EKCC RKDC LKLM KYLL EQLK ERFK DKKH LDKF SSYH VKTA FFHV CTQN PQDS QWDR KDLG LCFD NCVT YFLQ CLRT EKLE NYFI PEFN LFSS NLID KRSK EFLT KQIE YERN NEFP VFDE F
Gene ID:115004
Uniprot:Q8N884
Cellular Location:Cytoplasm, cytosol
Calculated MW:49kDa/58kDa
Observed MW:59kDa
Synonyms:MB21D1, C6orf150, cGAS, h-cGAS, CGAS
Background:
UniProt Protein Function:MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
UniProt Protein Details:

Protein type:EC 2.7.7.86; Enzyme, cellular metabolism

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: cytosol

Molecular Function:DNA binding; GTP binding; metal ion binding; ATP binding

Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response

UniProt Code:Q8N884
NCBI GenInfo Identifier:115511030
NCBI Gene ID:115004
NCBI Accession:NP_612450.2
UniProt Secondary Accession:Q8N884,Q14CV6, Q32NC9, Q5SWL0, Q5SWL1, Q96E45, L0L2J9
UniProt Related Accession:Q8N884
Molecular Weight:58.3 kDa
NCBI Full Name:cyclic GMP-AMP synthase
NCBI Synonym Full Names:Mab-21 domain containing 1
NCBI Official Symbol:MB21D1  
NCBI Official Synonym Symbols:cGAS; h-cGAS; C6orf150  
NCBI Protein Information:cyclic GMP-AMP synthase; cGAMP synthase; protein MB21D1; mab-21 domain-containing protein 1
UniProt Protein Name:Cyclic GMP-AMP synthase
UniProt Synonym Protein Names:Mab-21 domain-containing protein 1
UniProt Gene Name:MB21D1  
UniProt Entry Name:CGAS_HUMAN
Anti-cGAS Antibody (CAB8335)Western blot - cGAS Rabbit pAb (CAB8335)
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