Anti-cGAS Antibody (CAB20125)

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SKU:
CAB20125
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MB21D1
Synonyms:
C6orf150
Synonyms:
h-cGAS
Research Area:
Cell Biology

Description

Product Name:cGAS Rabbit pAb
Product Code:CAB20125
Size:20uL, 50uL, 100uL
Synonyms:MB21D1, C6orf150, cGAS, h-cGAS, CGAS
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 400-522 of human cGAS (NP_612450.2).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HeLa, Mouse testis, Mouse thymus, Mouse brain, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 400-522 of human cGAS (NP_612450.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:115004
Uniprot:Q8N884
Cellular Location:Cytoplasm, cytosol
Calculated MW:49kDa/58kDa
Observed MW:Refer to figures
UniProt Protein Function:MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
UniProt Protein Details:

Protein type:EC 2.7.7.86; Enzyme, cellular metabolism

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: cytosol

Molecular Function:DNA binding; GTP binding; metal ion binding; ATP binding

Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response

UniProt Code:Q8N884
NCBI GenInfo Identifier:115511030
NCBI Gene ID:115004
NCBI Accession:NP_612450.2
UniProt Secondary Accession:Q8N884,Q14CV6, Q32NC9, Q5SWL0, Q5SWL1, Q96E45, L0L2J9
UniProt Related Accession:Q8N884
Molecular Weight:58.3 kDa
NCBI Full Name:cyclic GMP-AMP synthase
NCBI Synonym Full Names:Mab-21 domain containing 1
NCBI Official Symbol:MB21D1  
NCBI Official Synonym Symbols:cGAS; h-cGAS; C6orf150  
NCBI Protein Information:cyclic GMP-AMP synthase; cGAMP synthase; protein MB21D1; mab-21 domain-containing protein 1
UniProt Protein Name:Cyclic GMP-AMP synthase
UniProt Synonym Protein Names:Mab-21 domain-containing protein 1
UniProt Gene Name:MB21D1  
UniProt Entry Name:CGAS_HUMAN
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