Anti-cGAS Antibody (CAB20125)
- SKU:
- CAB20125
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MB21D1
- Synonyms:
- C6orf150
- Synonyms:
- h-cGAS
- Research Area:
- Cell Biology
Description
| Product Name: | cGAS Rabbit pAb |
| Product Code: | CAB20125 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MB21D1, C6orf150, cGAS, h-cGAS, CGAS |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-522 of human cGAS (NP_612450.2). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HeLa, Mouse testis, Mouse thymus, Mouse brain, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-522 of human cGAS (NP_612450.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 115004 |
| Uniprot: | Q8N884 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 49kDa/58kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. |
| UniProt Protein Details: | Protein type:EC 2.7.7.86; Enzyme, cellular metabolism Chromosomal Location of Human Ortholog: 6q13 Cellular Component: cytosol Molecular Function:DNA binding; GTP binding; metal ion binding; ATP binding Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response |
| UniProt Code: | Q8N884 |
| NCBI GenInfo Identifier: | 115511030 |
| NCBI Gene ID: | 115004 |
| NCBI Accession: | NP_612450.2 |
| UniProt Secondary Accession: | Q8N884,Q14CV6, Q32NC9, Q5SWL0, Q5SWL1, Q96E45, L0L2J9 |
| UniProt Related Accession: | Q8N884 |
| Molecular Weight: | 58.3 kDa |
| NCBI Full Name: | cyclic GMP-AMP synthase |
| NCBI Synonym Full Names: | Mab-21 domain containing 1 |
| NCBI Official Symbol: | MB21D1 |
| NCBI Official Synonym Symbols: | cGAS; h-cGAS; C6orf150 |
| NCBI Protein Information: | cyclic GMP-AMP synthase; cGAMP synthase; protein MB21D1; mab-21 domain-containing protein 1 |
| UniProt Protein Name: | Cyclic GMP-AMP synthase |
| UniProt Synonym Protein Names: | Mab-21 domain-containing protein 1 |
| UniProt Gene Name: | MB21D1 |
| UniProt Entry Name: | CGAS_HUMAN |
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