Cell Biology Antibodies 8
Anti-CFHR1 Antibody (CAB2743)
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- SKU:
- CAB2743
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CFHR1 Antibody |
| Antibody SKU: | CAB2743 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-330 of human CFHR1 (NP_002104.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, NCI-H460, Mouse liver, Mouse lung, Mouse heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-330 of human CFHR1 (NP_002104.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PTVQ NAHI LSRQ MSKY PSGE RVRY ECRS PYEM FGDE EVMC LNGN WTEP PQCK DSTG KCGP PPPI DNGD ITSF PLSV YAPA SSVE YQCQ NLYQ LEGN KRIT CRNG QWSE PPKC LHPC VISR EIME NYNI ALRW TAKQ KLYL RTGE SAEF VCKR GYRL SSRS HTLR TTCW DGKL EYPT CAKR |
| Gene ID: | 3078 |
| Uniprot: | Q03591 |
| Cellular Location: | Secreted |
| Calculated MW: | 37kDa |
| Observed MW: | 43kDa |
| Synonyms: | CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2 |
| Background: | This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. |
| UniProt Protein Function: | CFHR1: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q32 Cellular Component: extracellular space Biological Process: complement activation Disease: Macular Degeneration, Age-related, 1; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q03591 |
| NCBI GenInfo Identifier: | 218512041 |
| NCBI Gene ID: | 3078 |
| NCBI Accession: | Q03591.2 |
| UniProt Related Accession: | Q03591 |
| Molecular Weight: | |
| NCBI Full Name: | Complement factor H-related protein 1 |
| NCBI Synonym Full Names: | complement factor H related 1 |
| NCBI Official Symbol: | CFHR1 |
| NCBI Official Synonym Symbols: | CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P |
| NCBI Protein Information: | complement factor H-related protein 1 |
| UniProt Protein Name: | Complement factor H-related protein 1 |
| UniProt Synonym Protein Names: | H factor-like protein 1; H-factor-like 1; H36 |
| UniProt Gene Name: | CFHR1 |
| UniProt Entry Name: | FHR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CFHR1 antibody (CAB2743) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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