Cell Cycle Antibodies 1

Anti-CETN1 Antibody (CAB3784)

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SKU:
CAB3784
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-CETN1 Antibody
Antibody SKU:CAB3784
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CETN1 (NP_004057.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Jurkat, MCF7, THP-1, HeLa, Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CETN1 (NP_004057.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASG FKKP SAAS TGQK RKVA PKPE LTED QKQE VREA FDLF DVDG SGTI DAKE LKVA MRAL GFEP RKEE MKKM ISEV DREG TGKI SFND FLAV MTQK MSEK DTKE EILK AFRL FDDD ETGK ISFK NLKR VANE LGEN LTDE ELQE MIDE ADRD GDGE VNEE EFLR IMKK TSLY
Gene ID:1068
Uniprot:Q12798
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:19kDa
Observed MW:20kDa
Synonyms:CETN1, CEN1, CETN, centrin-1
Background:The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.
UniProt Protein Function:CETN1: Plays a fundamental role in microtubule-organizing center structure and function. Belongs to the centrin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: centriole; spindle pole; centrosome; photoreceptor connecting cilium

Molecular Function:protein binding; microtubule binding; G-protein beta/gamma-subunit binding; calcium ion binding; heterotrimeric G-protein binding

Biological Process: mitosis; cell division

NCBI Summary:The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
UniProt Code:Q12798
NCBI GenInfo Identifier:2493440
NCBI Gene ID:1068
NCBI Accession:Q12798.1
UniProt Secondary Accession:Q12798,B2R536,
UniProt Related Accession:Q12798
Molecular Weight:172
NCBI Full Name:Centrin-1
NCBI Synonym Full Names:centrin, EF-hand protein, 1
NCBI Official Symbol:CETN1  
NCBI Official Synonym Symbols:CEN1; CETN  
NCBI Protein Information:centrin-1; caltractin; EF-hand protein; calcium binding protein
UniProt Protein Name:Centrin-1
UniProt Synonym Protein Names:Caltractin isoform 2
Protein Family:Centrin
UniProt Gene Name:CETN1  
UniProt Entry Name:CETN1_HUMAN
Anti-CETN1 Antibody (CAB3784)Western blot analysis of extracts of various cell lines, using CETN1 antibody (CAB3784) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-CETN1 Antibody (CAB3784)Immunohistochemistry of paraffin-embedded human liver damage using CETN1 antibody (CAB3784) at dilution of 1:100 (40x lens).
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