Signal Transduction Antibodies 2

Anti-CES3 Antibody (CAB4558)

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SKU:
CAB4558
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CES3
Synonyms:
ES31

Description

Product Name:CES3 Rabbit pAb
Product Code:CAB4558
Size:20uL, 50uL, 100uL
Synonyms:CES3, ES31
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, HT-29, Mouse small intestine, Mouse large intestine, Rat liver, Rat small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WPLA QKIA NTLA CSSS SPAE MVQC LQQK EGEE LVLS KKLK NTIY PLTV DGTV FPKS PKEL LKEK PFHS VPFL MGVN NHEF SWLI PRGW GLLD TMEQ MSRE DMLA ISTP VLTS LDVP PEMM PTVI DEYL GSNS DAQA KCQA FQEF MGDV FINV PTVS FSRY LRDS GSPV FFYE FQHR PSSF AKIK PAWV KADH GAEG AFVF GGPF LMDE SSRL EATE EEKQ LSLT MMAQ WTHF ARTG DPNS KALP PWPQ FNQA EQYL EINP VPRA GQKF REAW MQFW SETL PSKI QQWH QKQK NRKA QEDL
Gene ID:23491
Uniprot:Q6UWW8
Cellular Location:Endoplasmic reticulum lumen
Calculated MW:24kDa/62kDa
Observed MW:62kDa
UniProt Protein Function:CES3: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. Belongs to the type-B carboxylesterase/lipase family.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Secreted, signal peptide; Secreted; Hydrolase; EC 3.1.1.1

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space; endoplasmic reticulum lumen

Biological Process: metabolic process

NCBI Summary:This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
UniProt Code:Q6UWW8
NCBI GenInfo Identifier:74758561
NCBI Gene ID:23491
NCBI Accession:Q6UWW8.1
UniProt Secondary Accession:Q6UWW8,Q7Z6J1, Q9H6X7, B2Z3W9, F5H242,
UniProt Related Accession:Q6UWW8
Molecular Weight:24,106 Da
NCBI Full Name:Carboxylesterase 3
NCBI Synonym Full Names:carboxylesterase 3
NCBI Official Symbol:CES3  
NCBI Official Synonym Symbols:ES31  
NCBI Protein Information:carboxylesterase 3; esterase 31; carboxylesterase 3 (brain); liver carboxylesterase 31 homolog
UniProt Protein Name:Carboxylesterase 3
UniProt Synonym Protein Names:Liver carboxylesterase 31 homolog
Protein Family:Carboxylesterase
UniProt Gene Name:CES3  
UniProt Entry Name:EST3_HUMAN
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