Cell Biology Antibodies 11
Anti-Ceruloplasmin Antibody (CAB7658)
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- SKU:
- CAB7658
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Ceruloplasmin Antibody |
| Antibody SKU: | CAB7658 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human Ceruloplasmin (NP_000087.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HL-60, B cells, Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human Ceruloplasmin (NP_000087.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KEKH YYIG IIET TWDY ASDH GEKK LISV DTEH SNIY LQNG PDRI GRLY KKAL YLQY TDET FRTT IEKP VWLG FLGP IIKA ETGD KVYV HLKN LASR PYTF HSHG ITYY KEHE GAIY PDNT TDFQ RADD KVYP GEQY TYML LATE EQSP GEGD GNCV TRIY HSHI DAPK DIAS GLIG PLII CKKD SLDK EKEK HIDR EFVV MFSV VDEN FSWY LEDN IKTY CSEP EKVD KDNE DFQE SNRM YSVN GYTF GSLP GLSM CAED RVKW YLFG MGNE VDVH AAFF H |
| Gene ID: | 1356 |
| Uniprot: | P00450 |
| Cellular Location: | Secreted |
| Calculated MW: | 122kDa |
| Observed MW: | 119-130kDa |
| Synonyms: | CP, CP-2 |
| Background: | The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. |
| UniProt Protein Function: | CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. |
| UniProt Protein Details: | Protein type:Secreted; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q23-q25 Cellular Component: extracellular space; lysosomal membrane; extracellular region Molecular Function:ferroxidase activity; copper ion binding; chaperone binding Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport Disease: Aceruloplasminemia |
| UniProt Code: | P00450 |
| NCBI GenInfo Identifier: | 4557485 |
| NCBI Gene ID: | 1356 |
| NCBI Accession: | NP_000087 |
| UniProt Related Accession: | P00450 |
| Molecular Weight: | 122,205 Da |
| NCBI Full Name: | ceruloplasmin |
| NCBI Synonym Full Names: | ceruloplasmin (ferroxidase) |
| NCBI Official Symbol: | CP |
| NCBI Official Synonym Symbols: | CP-2 |
| NCBI Protein Information: | ceruloplasmin |
| UniProt Protein Name: | Ceruloplasmin |
| UniProt Synonym Protein Names: | Ferroxidase |
| Protein Family: | Ceruloplasmin |
| UniProt Gene Name: | CP |
| UniProt Entry Name: | CERU_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Ceruloplasmin Antibody (CAB7658) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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