Anti-Ceruloplasmin Antibody (CAB20229)
- SKU:
- CAB20229
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CP
- Synonyms:
- CP-2
- Research Area:
- Cell Biology
Description
| Product Name: | Ceruloplasmin Rabbit mAb |
| Product Code: | CAB20229 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CP, CP-2 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human Ceruloplasmin. |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse serum, Rat testis, Rat serum |
| Immunogen: | A synthetic peptide of human Ceruloplasmin. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1356 |
| Uniprot: | P00450 |
| Cellular Location: | Secreted |
| Calculated MW: | 122kDa |
| Observed MW: | 140KDa |
| UniProt Protein Function: | CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. |
| UniProt Protein Details: | Protein type:Secreted; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q23-q25 Cellular Component: extracellular space; lysosomal membrane; extracellular region Molecular Function:ferroxidase activity; copper ion binding; chaperone binding Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport Disease: Aceruloplasminemia |
| UniProt Code: | P00450 |
| NCBI GenInfo Identifier: | 4557485 |
| NCBI Gene ID: | 1356 |
| NCBI Accession: | NP_000087 |
| UniProt Related Accession: | P00450 |
| Molecular Weight: | 122,205 Da |
| NCBI Full Name: | ceruloplasmin |
| NCBI Synonym Full Names: | ceruloplasmin (ferroxidase) |
| NCBI Official Symbol: | CP |
| NCBI Official Synonym Symbols: | CP-2 |
| NCBI Protein Information: | ceruloplasmin |
| UniProt Protein Name: | Ceruloplasmin |
| UniProt Synonym Protein Names: | Ferroxidase |
| Protein Family: | Ceruloplasmin |
| UniProt Gene Name: | CP |
| UniProt Entry Name: | CERU_HUMAN |
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