Cell Biology Antibodies 11
Anti-CER1 Antibody (CAB7354)
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- SKU:
- CAB7354
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CER1 Antibody |
| Antibody SKU: | CAB7354 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-267 of human CER1 (NP_005445.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-267 of human CER1 (NP_005445.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TRHQ DGRQ NQSS LSPV LLPR NQRE LPTG NHEE AEEK PDLF VAVP HLVA TSPA GEGQ RQRE KMLS RFGR FWKK PERE MHPS RDSD SEPF PPGT QSLI QPID GMKM EKSP LREE AKKF WHHF MFRK TPAS QGVI LPIK SHEV HWET CRTV PFSQ TITH EGCE KVVV QNNL CFGK CGSV HFPG AAQH SHTS CSHC LPAK FTTM HLPL NCTE LSSV IKVV MLVE ECQC KVKT EHED GHIL HAGS QDSF IPGV SA |
| Gene ID: | 9350 |
| Uniprot: | O95813 |
| Cellular Location: | Secreted |
| Calculated MW: | 30kDa |
| Observed MW: | 30kDa |
| Synonyms: | CER1, DAND4, cerberus |
| Background: | This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. |
| UniProt Protein Function: | CER1: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak. Belongs to the DAN family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 9p23-p22 Cellular Component: extracellular space; extracellular region Molecular Function:morphogen activity; protein homodimerization activity; cytokine activity Biological Process: BMP signaling pathway; anterior/posterior pattern formation; negative regulation of cell proliferation; nervous system development; negative regulation of activin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; ureteric bud development; gastrulation; determination of dorsal identity; bone mineralization; cell migration involved in gastrulation; negative regulation of BMP signaling pathway; anterior/posterior axis specification |
| NCBI Summary: | This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95813 |
| NCBI GenInfo Identifier: | 62510411 |
| NCBI Gene ID: | 9350 |
| NCBI Accession: | O95813.1 |
| UniProt Related Accession: | O95813 |
| Molecular Weight: | |
| NCBI Full Name: | Cerberus |
| NCBI Synonym Full Names: | cerberus 1, DAN family BMP antagonist |
| NCBI Official Symbol: | CER1 |
| NCBI Official Synonym Symbols: | DAND4 |
| NCBI Protein Information: | cerberus |
| UniProt Protein Name: | Cerberus |
| UniProt Synonym Protein Names: | Cerberus-related protein; DAN domain family member 4 |
| UniProt Gene Name: | CER1 |
| UniProt Entry Name: | CER1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CER1 Antibody (CAB7354) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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