Cell Cycle Antibodies 1
Anti-CEP63 Antibody (CAB15516)
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- SKU:
- CAB15516
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-CEP63 Antibody |
| Antibody SKU: | CAB15516 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CEP63 (NP_001035859.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, Mouse liver, Mouse thymus, Rat kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CEP63 (NP_001035859.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEAL LEGI QNRG HGGG FLTS CEAE LQEL MKQI DIMV AHKK SEWE GRTH ALET CLKI REQE LKSL RSQL DVTH KEVG MLHQ QVEE HEKI KQEM TMEY KQEL KKLH EELC ILKR SYEK LQKK QMRE FRGN TKNH REDR SEIE RLTA KIEE FRQK SLDW EKQR LIYQ QQVS SLEA QRKA LAEQ SEII QAQL VNRK QKLE SVEL SSQS EIQH LSSK LERA NDTI CANE LEIE RLTM RVND LVGT SMTV LQEQ QQKE EKLR ESEK LLEA LQEE KREL KAAL QSQE NLIH EARI QKEK LQEK VKAT |
| Gene ID: | 80254 |
| Uniprot: | Q96MT8 |
| Cellular Location: | Cytoplasm, centriolar satellite, centriole, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 55kDa/57kDa/63kDa/81kDa |
| Observed MW: | 73kDa |
| Synonyms: | CEP63, SCKL6 |
| Background: | This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. |
| UniProt Protein Function: | Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). |
| NCBI Summary: | This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96MT8 |
| NCBI GenInfo Identifier: | 56748851 |
| NCBI Gene ID: | 80254 |
| NCBI Accession: | Q96MT8.1 |
| UniProt Secondary Accession: | Q96MT8,Q96CR0, Q9H8F5, Q9H8N0, D3DND8, D3DND9, D3DNE0 |
| UniProt Related Accession: | Q96MT8 |
| Molecular Weight: | 55,591 Da |
| NCBI Full Name: | Centrosomal protein of 63 kDa |
| NCBI Synonym Full Names: | centrosomal protein 63 |
| NCBI Official Symbol: | CEP63 |
| NCBI Official Synonym Symbols: | SCKL6 |
| NCBI Protein Information: | centrosomal protein of 63 kDa |
| UniProt Protein Name: | Centrosomal protein of 63 kDa |
| Protein Family: | Centrosomal protein |
| UniProt Gene Name: | CEP63 |
| UniProt Entry Name: | CEP63_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CEP63 antibody (CAB15516) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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