Cell Biology Antibodies 18

Anti-CEP350 Antibody (CAB18301)

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SKU:
CAB18301
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CEP350 Antibody
Antibody SKU:CAB18301
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human CEP350.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human CEP350.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9857
Uniprot:Q5VT06
Cellular Location:
Calculated MW:350kDa
Observed MW:Refer to figures
Synonyms:CEP350, CAP350, GM133
Background:The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
UniProt Protein Function:CEP350: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.
UniProt Protein Details:

Protein type:Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: centrosome; cytoplasm; membrane; nucleoplasm; spindle

Molecular Function:microtubule binding; protein binding

NCBI Summary:The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q5VT06
NCBI GenInfo Identifier:171184451
NCBI Gene ID:9857
NCBI Accession:NP_055625.4
UniProt Secondary Accession:Q5VT06,O75068, Q8TDK3, Q8WY20,
UniProt Related Accession:Q5VT06
Molecular Weight:200kd
NCBI Full Name:centrosome-associated protein 350
NCBI Synonym Full Names:centrosomal protein 350
NCBI Official Symbol:CEP350  
NCBI Official Synonym Symbols:GM133; CAP350  
NCBI Protein Information:centrosome-associated protein 350
UniProt Protein Name:Centrosome-associated protein 350
UniProt Synonym Protein Names:Centrosome-associated protein of 350 kDa
Protein Family:Centrosome-associated protein
UniProt Gene Name:CEP350  
UniProt Entry Name:CE350_HUMAN
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