Cell Biology Antibodies 6
Anti-CEP170 Antibody (CAB15370)
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- SKU:
- CAB15370
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CEP170 Antibody |
| Antibody SKU: | CAB15370 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1505-1584 of human CEP170 (NP_055627.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1505-1584 of human CEP170 (NP_055627.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NMGF PSAM LPSP PKQK SSPV NNHH SPGQ TPTL GQPE ARAL HPAA VSAA AEFE NAES EADF SIHF NRFN PDGE EEDV TVQE |
| Gene ID: | 9859 |
| Uniprot: | Q5SW79 |
| Cellular Location: | Cytoplasm, centriole, centrosome, cytoskeleton, microtubule organizing center, spindle |
| Calculated MW: | 161kDa/164kDa/175kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CEP170, FAM68A, KAB, KIAA0470 |
| Background: | The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. |
| UniProt Protein Function: | CEP170: a centrosomal protein containing a forkhead associated (FHA) domain. Interacts with Polo-like kinase 1 (PLK1), binds microtubules, and is involved in bundling microtubules. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 1q44 Cellular Component: centriole; centrosome; microtubule; nuclear membrane; cytoplasm; spindle Molecular Function:protein binding |
| NCBI Summary: | The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5SW79 |
| NCBI GenInfo Identifier: | 109255230 |
| NCBI Gene ID: | 9859 |
| NCBI Accession: | NP_001035863.1 |
| UniProt Secondary Accession: | Q5SW79,O75058, Q5SW77, Q5SW78, Q7LGA9, Q86W31, Q9UQ08 Q9UQ09, |
| UniProt Related Accession: | Q5SW79 |
| Molecular Weight: | 164,539 Da |
| NCBI Full Name: | centrosomal protein of 170 kDa isoform beta |
| NCBI Synonym Full Names: | centrosomal protein 170kDa |
| NCBI Official Symbol: | CEP170 |
| NCBI Official Synonym Symbols: | KAB; FAM68A; KIAA0470 |
| NCBI Protein Information: | centrosomal protein of 170 kDa |
| UniProt Protein Name: | Centrosomal protein of 170 kDa |
| UniProt Synonym Protein Names: | KARP-1-binding protein; KARP1-binding protein |
| Protein Family: | Centrosomal protein |
| UniProt Gene Name: | CEP170 |
| UniProt Entry Name: | CE170_HUMAN |
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