Cell Biology Antibodies 6

Anti-CEP170 Antibody (CAB15370)

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SKU:
CAB15370
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CEP170 Antibody
Antibody SKU:CAB15370
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1505-1584 of human CEP170 (NP_055627.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1505-1584 of human CEP170 (NP_055627.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NMGF PSAM LPSP PKQK SSPV NNHH SPGQ TPTL GQPE ARAL HPAA VSAA AEFE NAES EADF SIHF NRFN PDGE EEDV TVQE
Gene ID:9859
Uniprot:Q5SW79
Cellular Location:Cytoplasm, centriole, centrosome, cytoskeleton, microtubule organizing center, spindle
Calculated MW:161kDa/164kDa/175kDa
Observed MW:Refer to figures
Synonyms:CEP170, FAM68A, KAB, KIAA0470
Background:The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.
UniProt Protein Function:CEP170: a centrosomal protein containing a forkhead associated (FHA) domain. Interacts with Polo-like kinase 1 (PLK1), binds microtubules, and is involved in bundling microtubules.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: centriole; centrosome; microtubule; nuclear membrane; cytoplasm; spindle

Molecular Function:protein binding

NCBI Summary:The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q5SW79
NCBI GenInfo Identifier:109255230
NCBI Gene ID:9859
NCBI Accession:NP_001035863.1
UniProt Secondary Accession:Q5SW79,O75058, Q5SW77, Q5SW78, Q7LGA9, Q86W31, Q9UQ08 Q9UQ09,
UniProt Related Accession:Q5SW79
Molecular Weight:164,539 Da
NCBI Full Name:centrosomal protein of 170 kDa isoform beta
NCBI Synonym Full Names:centrosomal protein 170kDa
NCBI Official Symbol:CEP170  
NCBI Official Synonym Symbols:KAB; FAM68A; KIAA0470  
NCBI Protein Information:centrosomal protein of 170 kDa
UniProt Protein Name:Centrosomal protein of 170 kDa
UniProt Synonym Protein Names:KARP-1-binding protein; KARP1-binding protein
Protein Family:Centrosomal protein
UniProt Gene Name:CEP170  
UniProt Entry Name:CE170_HUMAN
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