Cell Cycle Antibodies 2

Anti-Centrobin Antibody (CAB8277)

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SKU:
CAB8277
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:CNTROB Rabbit Polyclonal Antibody
Antibody SKU:CAB8277
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 604-903 of human CNTROB (NP_444279.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SW620
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 604-903 of human CNTROB (NP_444279.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PMAV ALKP VLQQ SREA RDEL PGAP PVLC SSSS DLSL LLGP SFQS QHSF QPLE PKPD LTSS TAGA FSAL GAFH PDHR AERP FPEE DPGP DGEG LLKQ GLPP AQLE GLKN FLHQ LLET VPQN NENP SVDL LPPK SGPL TVPS WEEA PQVP RIPP PVHK TKVP LAMA SSLF RVPE PPSS HSQG SGPS SGSP ERGG DGLT FPRQ LMEV SQLL RLYQ ARGW GALP AEDL LLYL KRLE HSGT DGRG DNVP RRNT DSRL GEIP RKEI PSQA VPRR LATA PKTE KPPA RKKS GHPA PSSM RSRG GVWR
Gene ID:116840
Uniprot:Q8N137
Cellular Location:Cytoplasm, centriole, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:63kDa/97kDa/101kDa/103kDa
Observed MW:101kDa
Synonyms:CNTROB, LIP8, PP1221, centrobin
Background:This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniProt Protein Function:LIP8: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: centriole; centrosome; cytoplasm

Molecular Function:protein binding; protein domain specific binding

Biological Process: centriole replication; centrosome separation

NCBI Summary:This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:Q8N137
NCBI GenInfo Identifier:74728485
NCBI Gene ID:116840
NCBI Accession:Q8N137.1
UniProt Secondary Accession:Q8N137,Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060 A6NHQ1,
UniProt Related Accession:Q8N137
Molecular Weight:97,113 Da
NCBI Full Name:Centrobin
NCBI Synonym Full Names:centrobin, centriole duplication and spindle assembly protein
NCBI Official Symbol:CNTROB  
NCBI Official Synonym Symbols:LIP8; PP1221  
NCBI Protein Information:centrobin
UniProt Protein Name:Centrobin
UniProt Synonym Protein Names:Centrosomal BRCA2-interacting protein; LYST-interacting protein 8
Protein Family:Centrobin
UniProt Gene Name:CNTROB  
UniProt Entry Name:CNTRB_HUMAN
Anti-Centrobin Polyclonal Antibody (CAB8277)Western blot analysis of extracts of SW620 cells, using CNTROB antibody (CAB8277) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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