Cell Biology Antibodies 11
Anti-CENPQ Antibody (CAB7628)
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- SKU:
- CAB7628
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CENPQ Antibody |
| Antibody SKU: | CAB7628 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEDL TNVS SLLN MERA RDKA NEEG LALL QEEI DKMV ETTE LMTG NIQS LKNK IQIL ASEV EEEE ERVK QMHQ INSS GVLS LPEL SQKT LKAP TLQK EILA LIPN QNAL LKDL DILH NSSQ MKSM STFI EEAY KKLD AS |
| Gene ID: | 55166 |
| Uniprot: | Q7L2Z9 |
| Cellular Location: | Chromosome, Nucleus, centromere |
| Calculated MW: | 30kDa |
| Observed MW: | 31kDa |
| Synonyms: | CENPQ, C6orf139, CENP-Q |
| Background: |
| UniProt Protein Function: | CENPQ: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6p12.3 Cellular Component: nucleoplasm; cytosol; chromosome, pericentric region; actin cytoskeleton Biological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle |
| NCBI Summary: | CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q7L2Z9 |
| NCBI GenInfo Identifier: | 40068061 |
| NCBI Gene ID: | 55166 |
| NCBI Accession: | NP_060602.2 |
| UniProt Secondary Accession: | Q7L2Z9,Q6IN61, Q9NVS5, A8KAF1, |
| UniProt Related Accession: | Q7L2Z9 |
| Molecular Weight: | 30,595 Da |
| NCBI Full Name: | centromere protein Q |
| NCBI Synonym Full Names: | centromere protein Q |
| NCBI Official Symbol: | CENPQ |
| NCBI Official Synonym Symbols: | CENP-Q; C6orf139 |
| NCBI Protein Information: | centromere protein Q |
| UniProt Protein Name: | Centromere protein Q |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPQ |
| UniProt Entry Name: | CENPQ_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using CENPQ antibody (CAB7628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using CENPQ antibody (CAB7628) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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