Cell Biology Antibodies 15
Anti-CENPF Antibody (CAB18644)
- SKU:
- CAB18644
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CENPF Antibody |
| Antibody SKU: | CAB18644 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CENPF. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, |
| Positive Samples: | HeLa, Mouse brain |
| Immunogen: | Recombinant protein of human CENPF. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1063 |
| Uniprot: | P49454 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 358kDa |
 | Western blot - CENPF Rabbit pAb (CAB18644) |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | CENPF: a nuclear matrix protein that assembles onto kinetochores at late G2. Is hyperphosphorylated during mitosis and rapidly degraded after mitosis. Involved in chromosome segregation during mitosis. Interacts with retinoblastoma protein (RB), CENP-E and BUBR1. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Nuclear envelope; Cell cycle regulation; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q41 Cellular Component: spindle pole; nuclear matrix; pronucleus; nuclear envelope; cytosol; kinetochore; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; spindle; outer kinetochore of condensed chromosome; midbody; nucleus; chromatin; chromosome, pericentric region Molecular Function:protein C-terminus binding; dynein binding; protein binding; protein homodimerization activity; chromatin binding; transcription factor binding Biological Process: response to drug; mitosis; kinetochore assembly; muscle development; regulation of cell cycle; chromosome segregation; cell proliferation; protein transport; cell division; regulation of G2/M transition of mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; metaphase plate congression; mitotic cell cycle; G2/M transition of mitotic cell cycle; cell differentiation; negative regulation of transcription, DNA-dependent; regulation of striated muscle development Disease: Ciliary Dyskinesia, Primary, 31 |
| NCBI Summary: | This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49454 |
| NCBI GenInfo Identifier: | 55770834 |
| NCBI Gene ID: | 1063 |
| NCBI Accession: | NP_057427.3 |
| UniProt Secondary Accession: | P49454,Q13171, Q13246, Q5VVM7, |
| UniProt Related Accession: | P49454 |
| Molecular Weight: | 367,764 Da |
| NCBI Full Name: | centromere protein F |
| NCBI Synonym Full Names: | centromere protein F, 350/400kDa |
| NCBI Official Symbol: | CENPF |
| NCBI Official Synonym Symbols: | CENF; hcp-1; PRO1779 |
| NCBI Protein Information: | centromere protein F; mitosin; AH antigen; kinetochore protein CENPF; CENP-F kinetochore protein; cell-cycle-dependent 350K nuclear protein; centromere protein F, 350/400ka (mitosin); centromere protein F, 350/400kDa (mitosin) |
| UniProt Protein Name: | Centromere protein F |
| UniProt Synonym Protein Names: | AH antigen; Kinetochore protein CENPF; Mitosin |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPF |
| UniProt Entry Name: | CENPF_HUMAN |
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