Anti-CELF1 Antibody (CAB1150)
- SKU:
- CAB1150
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BRUNOL2
- Synonyms:
- CUG-BP
- Synonyms:
- CUGBP
- Synonyms:
- CUGBP1
- Synonyms:
- EDEN-BP
- Synonyms:
- NAB50
- Synonyms:
- NAPOR
- Synonyms:
- hNab50
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | CELF1 Rabbit mAb |
| Product Code: | CAB1150 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CELF1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human CELF1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10658 |
| Uniprot: | Q92879 |
| Calculated MW: | 52kDa |
| Observed MW: | 46kDa |
| UniProt Protein Function: | CELF1: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. Belongs to the CELF/BRUNOL family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA processing; Cell development/differentiation Chromosomal Location of Human Ortholog: 11p11 Cellular Component: nucleoplasm; membrane; cytoplasm; ribonucleoprotein complex; nucleus Molecular Function:mRNA binding; protein binding; RNA binding; translation initiation factor binding; BRE binding; translation repressor activity, nucleic acid binding; nucleotide binding Biological Process: mRNA splice site selection; embryonic development; regulation of RNA splicing; negative regulation of translation; positive regulation of multicellular organism growth; mRNA processing; spermatid development; germ cell development; RNA interference |
| NCBI Summary: | Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92879 |
| NCBI GenInfo Identifier: | 17374605 |
| NCBI Gene ID: | 10658 |
| NCBI Accession: | Q92879.2 |
| UniProt Secondary Accession: | Q92879,Q4LE52, Q9NP83, Q9NR06, B4E2U5, D3DQS0, F8W940 |
| UniProt Related Accession: | Q92879 |
| Molecular Weight: | 51,992 Da |
| NCBI Full Name: | CUGBP Elav-like family member 1 |
| NCBI Synonym Full Names: | CUGBP, Elav-like family member 1 |
| NCBI Official Symbol: | CELF1 |
| NCBI Official Synonym Symbols: | CUGBP; NAB50; NAPOR; CUG-BP; CUGBP1; hNab50; BRUNOL2; EDEN-BP |
| NCBI Protein Information: | CUGBP Elav-like family member 1; CELF-1; CUG-BP1; bruno-like 2; EDEN-BP homolog; bruno-like protein 2; CUG RNA-binding protein; deadenylation factor CUG-BP; RNA-binding protein BRUNOL-2; CUG-BP- and ETR-3-like factor 1; CUG triplet repeat RNA-binding protein 1; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA-binding protein 1; embryo deadenylation element binding protein; 50 kDa nuclear polyadenylated RNA-binding protein; nuclear polyadenylated RNA-binding protein, 50-kD; embryo deadenylation element-binding protein homolog |
| UniProt Protein Name: | CUGBP Elav-like family member 1 |
| UniProt Synonym Protein Names: | 50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Deadenylation factor CUG-BP; Embryo deadenylation element-binding protein homolog; EDEN-BP homolog; RNA-binding protein BRUNOL-2 |
| Protein Family: | CUGBP Elav-like family |
| UniProt Gene Name: | CELF1 |
| UniProt Entry Name: | CELF1_HUMAN |
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