Signal Transduction Antibodies 1

Anti-CELA3B Antibody (CAB13714)

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SKU:
CAB13714
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CELA3B Antibody
Antibody SKU:CAB13714
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-190 of human CELA3B (NP_031378.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Rat pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-190 of human CELA3B (NP_031378.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TYQV VLGE YDRA VKEG PEQV IPIN SGDL FVHP LWNR SCVA CGND IALI KLSR SAQL GDAV QLAS LPPA GDIL PNET PCYI TGWG RLYT NGPL PDKL QEAL LPVV DYEH CSR
Gene ID:23436
Uniprot:P08861
Cellular Location:
Calculated MW:29kDa
Observed MW:29kDa
Synonyms:CELA3B, CBPP, ELA3B
Background:Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
UniProt Protein Function:CELA3B: Efficient protease with alanine specificity but only little elastolytic activity. Belongs to the peptidase S1 family. Elastase subfamily.
UniProt Protein Details:

Protein type:EC 3.4.21.70; Protease

Chromosomal Location of Human Ortholog: 1p36.12

Molecular Function:peptidase activity; serine-type endopeptidase activity

Biological Process: cholesterol metabolic process; proteolysis

NCBI Summary:Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
UniProt Code:P08861
NCBI GenInfo Identifier:317373457
NCBI Gene ID:23436
NCBI Accession:P08861.3
UniProt Secondary Accession:P08861,P11423, Q5VU28, Q5VU29, Q5VU30, B2RE44,
UniProt Related Accession:P08861
Molecular Weight:29,263 Da
NCBI Full Name:Chymotrypsin-like elastase family member 3B
NCBI Synonym Full Names:chymotrypsin-like elastase family, member 3B
NCBI Official Symbol:CELA3B  
NCBI Official Synonym Symbols:E1; CBPP; EL-1; ELA3B  
NCBI Protein Information:chymotrypsin-like elastase family member 3B; elastase 1; protease E; elastase-3B; proteinase E; elastase IIIB; fecal elastase 1; pancreatic elastase 1; elastase 3B, pancreatic; pancreatic endopeptidase E; cholesterol-binding pancreatic protease
UniProt Protein Name:Chymotrypsin-like elastase family member 3B
UniProt Synonym Protein Names:Elastase IIIB; Elastase-3B; Protease E
Protein Family:Chymotrypsin-like elastase family
UniProt Gene Name:CELA3B  
UniProt Entry Name:CEL3B_HUMAN
Anti-CELA3B Antibody (CAB13714)Western blot analysis of extracts of rat pancreas, using CELA3B antibody (CAB13714) at 1:3000 dilution.
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