Metabolism Antibodies 2

Anti-CEL Antibody (CAB7652)

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SKU:
CAB7652
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-CEL Antibody
Antibody SKU:CAB7652
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CEL
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Mouse spleen
Immunogen:A synthetic peptide of human CEL
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1056
Uniprot:P19835
Cellular Location:Secreted
Calculated MW:71kDa/79kDa
Observed MW:71kDa
Synonyms:CEL, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8
Background:The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.
UniProt Protein Function:CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - glycerolipid; Lipid Metabolism - steroid biosynthesis; Secreted, signal peptide; EC 3.1.1.13; EC 3.1.1.3; Secreted; Lipase

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function:heparin binding; sterol esterase activity; triacylglycerol lipase activity; protein binding; hydrolase activity; acylglycerol lipase activity; catalytic activity

Biological Process: intestinal lipid catabolic process; triacylglycerol metabolic process; cholesterol absorption; fatty acid catabolic process; lipid metabolic process; protein amino acid esterification; pancreatic juice secretion; cholesterol catabolic process; lipid digestion

Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction

NCBI Summary:The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
UniProt Code:P19835
NCBI GenInfo Identifier:251757481
NCBI Gene ID:1056
NCBI Accession:P19835.3
UniProt Secondary Accession:P19835,Q16398, Q5T7U7, Q9UCH1, Q9UP41,
UniProt Related Accession:P19835
Molecular Weight:71,834 Da
NCBI Full Name:Bile salt-activated lipase
NCBI Synonym Full Names:carboxyl ester lipase
NCBI Official Symbol:CEL  
NCBI Official Synonym Symbols:BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8  
NCBI Protein Information:bile salt-activated lipase; bile salt-dependent lipase, oncofetal isoform; bucelipase; carboxyl ester hydrolase; carboxyl ester lipase (bile salt-stimulated lipase); cholesterol esterase; fetoacinar pancreatic protein; lysophospholipase, pancreatic
UniProt Protein Name:Bile salt-activated lipase
UniProt Synonym Protein Names:Bile salt-stimulated lipase; BSSL; Bucelipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase
Protein Family:Bile salt-activated lipase
UniProt Gene Name:CEL  
UniProt Entry Name:CEL_HUMAN
Anti-CEL Antibody (CAB7652)Western blot analysis of extracts of various cell lines, using CEL antibody (CAB7652) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
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