Cell Biology Antibodies 1

Anti-CECR2 Antibody (CAB10143)

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SKU:
CAB10143
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CECR2 Antibody
Antibody SKU:CAB10143
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-370 of human CECR2 (NP_113601.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-370 of human CECR2 (NP_113601.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VQGK SNGE LSLS RESE GQKN VSSI PGKT GKRR GRPP KRKK LQEE ILLS EKQE ENSL ASEP QTRH GSQG PGQG TWWL LCQT EEEW RQVT ESFR ERTS LRER QLYK LLSE DFLP EICN MIAQ KGKR PQRT KAEL HPRW MSDH LSIK PVKQ EETP VLTR IEKQ KRKE EEEE RQIL LAVQ KKEQ EQML KEER KREL EEKV KAVE G
Gene ID:27443
Uniprot:Q9BXF3
Cellular Location:
Calculated MW:58kDa/162kDa/164kDa
Observed MW:164kDa
Synonyms:CECR2
Background:This gene encodes a bromodomain-containing protein that is involved in chromatin remodeling, and may additionally play a role in DNA damage response. The encoded protein functions as part of an ATP-dependent complex that is involved in neurulation. This gene is a candidate gene for Cat Eye Syndrome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes. In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465).
NCBI Summary:This gene encodes a bromodomain-containing protein that is involved in chromatin remodeling, and may additionally play a role in DNA damage response. The encoded protein functions as part of an ATP-dependent complex that is involved in neurulation. This gene is a candidate gene for Cat Eye Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Code:Q9BXF3
NCBI GenInfo Identifier:586798144
NCBI Gene ID:27443
NCBI Accession:NP_001276976.1
UniProt Secondary Accession:Q9BXF3,Q658Z4, Q96P58, Q9C0C3, A8MS90, A8MX16,
UniProt Related Accession:Q9BXF3
Molecular Weight:58,108 Da
NCBI Full Name:cat eye syndrome critical region protein 2 isoform 1
NCBI Synonym Full Names:CECR2, histone acetyl-lysine reader
NCBI Official Symbol:CECR2  
NCBI Protein Information:cat eye syndrome critical region protein 2
UniProt Protein Name:Cat eye syndrome critical region protein 2
Protein Family:Cat eye syndrome critical region protein
UniProt Gene Name:CECR2  
Anti-CECR2 Antibody (CAB10143)Western blot analysis of extracts of various cell lines, using CECR2 antibody (CAB10143) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.
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